Relationship between eNOS gene polymorphism and main complications in premature infants
10.19405/j.cnki.issn1000-1492.2025.04.019
- Author:
Xiaoyan Li
1
;
Bing Li
2
;
Jia'an Wang
1
;
Xian Dong
1
;
Huiqin Wang
1
;
Haijuan Zhu
3
;
Bin Zhang
4
Author Information
1. Dept of Neonatology，Anhui Women and Children Medical Center ( Hefei Maternal and Child Health Hospital) ，Hefei 230031
2. Dept of General Pediatrics，Anhui Women and Children Medical Center ( Hefei Maternal and Child Health Hospital) ，Hefei 230031
3. Dept of Anesthesiology， Anhui Women and Children Medical Center ( Hefei Maternal and Child Health Hospital) ，Hefei 230031
4. Dept of Science and Education ，Anhui Women and Children Medical Center ( Hefei Maternal and Child Health Hospital) ，Hefei 230031
- Publication Type:Journal Article
- Keywords:
endothelial nitric oxide synthase;
gene polymorphism;
bronchopulmonary dysplasia;
retinopathy pre- maturity;
preterm infants
- From:
Acta Universitatis Medicinalis Anhui
2025;60(4):719-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the polymorphism of endothelial nitric oxide synthase(eNOS) gene in umbilical cord blood of preterm infants and its relationship with major complications in preterm infants.
Methods :A total of 254 preterm infants(<37 weeks) who were hospitalized were selected as the study subjects. Umbilical cord blood was collected at delivery to determine the genotypes and alleles of eNOS gene at three loci: rs61722009, rs2070744,and rs1799983. Clinical data of the preterm infants were recorded, and the relationship between eNOS gene polymorphism and major complications in preterm infants was analyzed.
Results:(1) The TC+CC genotype at locus rs2070744 was an independent risk factor for bronchopulmonary dysplasia(BPD) in preterm infants, with an OR(95%CI) of 1.266(1.017-1.577).(2) The GT+TT genotype at locus rs1799983 was an independent risk factor for retinopathy prematurity(ROP), with an OR(95%CI) of 1.184(1.008-1.391).(3) The AB+AA genotype at locus rs61722009 was also an independent risk factor for ROP,with an OR(95%CI) of 1.335(1.033-1. 726).(4) There was no significant relationship between gene polymorphism and the occurrence of respiratory distress syndrome( RDS) and periventricular-intraventricular hemorrhage( PIVH).
Conclusion :eNOS gene polymorphism is associated with the occurrence of BPD and ROP in preterm infants. The evaluation of e NOS gene polymorphism by umbilical cord blood measurement is helpful for the prevention and correct management of some serious complications.
- Full text:2026012717283234451eNOS基因多态性与早产儿主要并发症的关系研究_李小燕.pdf
