The association of obesity and inflammatory cytokines in adolescent patients with major depressive disorder
10.19405/j.cnki.issn1000-1492.2025.04.012
- Author:
Mingru Hao
1
;
Lewei Liu
1
;
Lei Xia
2
;
Feng Geng
3
;
Daming
;
Mo
4
;
Huanzhong Liu
5
Author Information
1. School of Mental Health and Psychological Sciences，Anhui Medical University，Hefei 230032; Dept of Psychiatry，Chaohu Hospital of Anhui Medical University，Hefei 238000; Anhui Psychiatric Center，Hefei 238000
2. Dept of Psychiatry，Chaohu Hospital of Anhui Medical University，Hefei 238000; Anhui Psychiatric Center，Hefei 238000
3. Dept of Psychology and Sleep Medicine，The Second Affiliated Hospital of Anhui Medical University， Hefei 230601
4. Dept of Child and Adolescent Psychology，Hefei Fourth People 's Hospital，Hefei 230000;
5. Dept of Psychiatry，Chaohu Hospital of Anhui Medical University，Hefei 238000; Anhui Psychiatric Center，Hefei 238000; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization，Hefei 230000
- Publication Type:Journal Article
- Keywords:
adolescent;
major depressive disorder;
obesity;
inflammatory cytokines;
body mass index
- From:
Acta Universitatis Medicinalis Anhui
2025;60(4):670-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristic of obesity in adolescents with major depressive disorder and its relationship with inflammatory cytokines.
Methods : One hundred and forty adolescents with major depressive disorder were enrolled. According to the classification standard of body mass index(BMI) for adolescents in China, the patients were classified into underweight group, normal group, overweight group and obese group. The center for epidemiologic studies depression scale(CES-D) was used to evaluate symptoms of depression in patients, and ultrasensitive multiplex electrochemiluminescence detection technology was used to measure the levels of plasma inflammatory cytokines including interleukin(IL)-6,IL-17A,IL-1β,IL-6,IL-8 and tumour necrosis factor(TNF)-α. One-way ANOVA or Kruskal-WallisHtest and chi-square test were used for comparison between groups. Binary Logistic regression was used to analyze the influencing factors of obesity in adolescent patients with major depressive disorder.
Results :Among the 140 adolescent patients with major depressive disorder, wasting were 9.3%(13/140), overweight were 17.9%(25/140) and obesity were 6.4%(9/140) respectively. There were statistically significant differences in gender(χ2=8.301,P<0.05) and inflammatory cytokines IL-6(H=16.217,P<0.01), IL-8(H=10.926,P<0.05) and TNF-α(H=7.879,P<0.05) among the four groups. Analysis of covariance showed that the difference in levels of the inflammatory cytokine IL-6(F=4.486,P<0.01) remained statistically significant after controlling for age, gender and antidepressant use. The results of multiple comparisons showed that compared with the wasting group, the plasma IL-6(Z=-3.843,PBonferroni calibrate<0.01) were higher in the obese group; compared with the normal group, the obesity rate of males was higher than that of females(χ2=8.812,PBonferroni calibrate<0.01), and the level of IL-6 in the obese group(Z=-3.023,PBonferroni calibrate<0.05) was higher. Binary Logistic regression analysis showed that plasma IL-6(OR=2.500,P<0.01) and gender(OR=11.292,P<0.01) were independent influencing factors for obesity in patients with adolescent depressive disorders.
Conclusion :There are gender differences in obesity rates in adolescents with depressive disorders, and obesity is associated with elevated levels of inflammatory cytokines.
- Full text:2026012609584537526青少年抑郁障碍患者肥胖与炎症细胞因子的关联性研究_郝明茹.pdf
