Association of zinc finger protein 6 gene polymorphism with the occurrence of rectal cancer
10.19405/j.cnki.issn1000-1492.2025.04.011
- VernacularTitle:锌指蛋白6基因多态性与直肠癌发生的关联性
- Author:
Shan He
1
;
Fang Gao
1
;
Songhao Rong
1
;
Shuyi Ma
1
;
Li Gao
2
Author Information
1. chool of Medical Technology and Anesthesiology，Baotou Medical College，Baotou 014040;
2. College of Ecology and Environment，Baotou Teacher 's College，Baotou 014030
- Publication Type:Journal Article
- Keywords:
rectal cancer;
ZBED6;
single nucleotide polymorphism;
unconditional Logistic regression;
rs7552670;
correlation
- From:
Acta Universitatis Medicinalis Anhui
2025;60(4):664-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the relationship between the risk occurrence of rectal cancer and the single nucleotide polymorphisms(SNP) of zinc finger protein 6(ZBED6), and to provide the experimental basis for early diagnosis and treatment of rectal cancer.
Methods:Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technology was used to genotype the ZBED6 gene in 109 randomly selected rectal cancer patients and 110 unrelated healthy controls. To evaluate the relationship between alleles, genotypes and the risk of rectal cancer, unconditional Logistic regression analysis was used toORand 95%CI.
Results:The SNP rs7552670 of ZBED6 had significant correlation with the risk of rectal cancer. Compared with the population carrying the TT genotype, those carrying the TC genotype had a 2.653 fold increased risk of rectal cancer(TTvsTC:OR=2.635, 95%CI=1.501-4.690). Other SNPs had no significant correlation with the risk of rectal cancer.
Conclusion:There is an interaction between the polymorphisms of ZBED6(rs7552670) and rectal cancer. The population carried ZBED6 rs7552670 TC genotype had an growing risk of rectal cancer.
- Full text:2026012609544962739锌指蛋白6基因多态性与直肠癌发生的关联性_何珊.pdf
