Analysis of SLCO1B1 and ApoE genetic polymorphisms in patients of Han ethnic group with cardiovascular and cerebrovascular diseases from Anhui Province
10.19405/j.cnki.issn1000-1492.2025.04.005
- VernacularTitle:安徽汉族心脑血管疾病患者SLCO1B1和ApoE基因多态性分析
- Author:
Jie Li
1
;
Xiaowen Cheng
1
;
Xiang Xu
1
;
Chuanbo Ha
1
;
Wenjun Hu
1
;
Hui Tao
2
Author Information
1. Dept of Clinical Laboratory，The First Affiliated Hospital of Anhui Medical University，Hefei 230022)
2. Dept of Orthopedics，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- Keywords:
SLCO1B1;
ApoE;
genetic polymorphism;
statins;
Han ethnic group;
cardiovascular and cerebrovascu- lar diseases
- From:
Acta Universitatis Medicinalis Anhui
2025;60(4):619-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the distribution of solute carrier organic anion transporter family member 1B1(SLCO1B1) and apolipoprotein E(ApoE) gene polymorphisms in the patients of Han ethnic group with cardiovascular and cerebrovascular diseases from Anhui Province, in order to provide the basis for the individualized therapy of statins in clinical practice.
Methods:924 Han patients with cardiovascular and cerebrovascular diseases were selected. The SLCO1B1 and ApoE genotypes of the patients were detected by polymerase chain reaction-fluorescent probe method, and their distribution was compared among different genders and other regions in China.
Results:Seven SLCO1B1 gene subtypes were detected in 924 patients, including *1a/*1b(33.01%),*1b/*1b(41.45%), *1b/*15(12.34%), *1a/*1a(7.03%), *1a/*15(5.52%), *15/*15(0.54%) and *5/*5(0.11%), without detection of the two gene subtypes of *1a/*5 and *5/*15; the normal metabolic genotype I of SLCO1B1(*1a/*1a, *1a/*1b, *1b/*1b) accounted for the highest proportion in this population(81.49%), the intermediate metabolic genotype II and the weak metabolic genotype III of SLCO1B1 accounted for 17.86% and 0.65% respectively; six ApoE gene subtypes were detected, including E3/E3(66.78%), E3/E4(19.37%), E2/E3(9.63%), E4/E4(1.84%), E2/E4(1.73%) and E2/E2(0.65%); the E3 mass genotype(E2/E4, E3/E3) accounted for the highest proportion in this population(68.51%); there was no significant difference in the distribution of SLCO1B1 and ApoE genes between different genders; there was no significant difference in the distribution of SLCO1B1 between the Han population from Anhui and the South China and Central China, but a significant difference was found between the Anhui Han population and the Southwest China(P<0.05); the distribution of ApoE in the Anhui Han population demonstrated no statistically significant variation from those in South China and Southwest China, whereas significant differences were observed in comparison with Central China(P<0.05).
Conclusion:In the Han population with cardiovascular and cerebrovascular diseases in Anhui, the distributions of SLCO1B1 and ApoE gene polymorphisms show no significant gender differences but exhibit regional variations. These populations are predominantly characterized by class I normal metabolic genotype(SLCO1B1) and E3 mass genotypes(ApoE), indicating a higher tolerance to statin dosages and normal therapeutic efficacy in this cohort.
- Full text:2026012609335702395安徽汉族心脑血管疾病患者S...1和ApoE基因多态性分析_李洁.pdf
