Role of bile acids-gut microbiota interaction in the pathogenesis and treatment of cholestasis
10.19405/j.cnki.issn1000-1492.2025.03.027
- VernacularTitle:胆汁酸与肠道菌群互作在胆汁淤积发病和治疗中的作用
- Author:
Yinpei Tang
1
;
Zhengwang Zhu
1
;
Pingsheng Zhu
1
;
Qingchun Cai
2
;
Bing Wang
3
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450046
2. The Third Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003
3. Shanghai Jiaotong University School of Medicine Affiliated Sixth People 's Hospital，Shanghai 200240
- Publication Type:Review
- Keywords:
cholestasis;
bile acids;
gut microbiota;
enterohepatic circulation;
interaction;
mechanism
- From:
Acta Universitatis Medicinalis Anhui
2025;60(3):578-583
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Cholestasis can be seen in many acute and chronic liver diseases. If not intervened in time, persistent cholestasis can further progress to liver fibrosis, liver cirrhosis, liver failure, and even death. The pathogenesis of cholestasis is complex, and there is currently a lack of effective therapeutic drugs. Bile acids(BAs), the main component of bile, are synthesized from cholesterol in the liver as primary bile acids. After entering the intestine through the enterohepatic circulation, they are reshaped into secondary bile acids by gut microbiota. BAs can directly or indirectly affect the composition and function of gut microbiota, which in turn can regulate the synthesis and metabolism of BAs. The interaction between BAs and gut microbiota plays an important role in the pathogenesis and treatment of cholestasis. This review elucidates the bidirectional regulatory mechanisms between BAs and gut microbiota and their roles in the pathogenesis and treatment of cholestasis, aiming to provide insights and references for basic research and clinical practice related to cholestasis-associated diseases.
- Full text:2026012318583265846胆汁酸与肠道菌群互作在胆汁淤积发病和治疗中的作用_唐银佩.pdf
