The laboratory biomarkers of disease activity in ankylosing spondylitis
10.19405/j.cnki.issn1000-1492.2025.03.023
- Author:
Siming Gao
1
;
Wei Liu
1
;
Siliang Man
1
;
Hongchao Li
1
;
Hui Song
1
Author Information
1. Dept of Rheumatology，Beijing Jishuitan Hospital，Capital Medical University，Beijing 100010
- Publication Type:Journal Article
- Keywords:
ankylosing spondylitis;
disease activity;
laboratory biomarkers;
specificity;
sensibility
- From:
Acta Universitatis Medicinalis Anhui
2025;60(3):552-557, 564
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To analyze the correlation between different laboratory biomarkers and disease activity in ankylosing spondylitis and to compare their specificity and sensitivity in assessing disease activity.
Methods :Spearman correlation or Pearson correlation was used to analyze the correlation between disease activity and laboratory biomarkers. Receiver operating characteristic(ROC) was used to compare the sensitivity and specificity of each laboratory biomarker in evaluating disease activity.
Results : Hypersensitive C-reactive protein, fibrinogen, D-dimer, erythrocyte sediment rate, C-reactive protein, immuno-inflammatory index(platelet count×neutrophil count/lymphocyte count), fibrinogen/albumin ratio, albumin and pro-albumin were correlated with disease activity. The ratio of fibrinogen to albumin, fibrinogen, erythrocyte sedimentation rate, immuno-inflammatory index, C-reactive protein and hypersensitive C-reactive protein had good values in determining the disease activity.
Conclusion :Different laboratory biomarkers are correlated with the disease activity of ankylosing spondylitis, and some of them have better discriminating values for the disease activity.
- Full text:2026012318483137195强直性脊柱炎病情相关的血清学指标_郜司名.pdf
