Abnormal levels of oxidative stress and correlation analysis in patients with depression accompanied by non-suicidal self-injury
10.19405/j.cnki.issn1000-1492.2025.03.022
- Author:
Aiguo Zhang
1
;
Xiaojuan Hu
1
;
Chao Wang
1
;
Yang Zhang
1
;
Xulai Zhang
2
Author Information
1. Dept of Psychiatry，Affiliated Psychological Hospital of Anhui Medical University， Anhui Mental Health Center，The Fourth People 's Hospital of Hefei City，Hefei 230032
2. Dept of Psychiatry，Affiliated Psychological Hospital of Anhui Medical University， Anhui Mental Health Center，The Fourth People 's Hospital of Hefei City，Hefei 230032; Anhui Clinical Research Center for Mental Disorders，Hefei 230022
- Publication Type:Journal Article
- Keywords:
non-suicidal self-injury;
oxidative stress;
Ottawa self-injury scale;
depressive disorder
- From:
Acta Universitatis Medicinalis Anhui
2025;60(3):547-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the differences in oxidative stress levels between patients with and without non-suicidal self-injury(NSSI) behavior in depressive disorders, and their correlation with depressive symptoms, disease duration, and self-injury frequency.
Methods :A total of 95 subjects were included in the study, including 65 patients with depression(patient group). They were divided into NSSI subgroup(31 cases) and Non-NSSI subgroup(34 cases) based on whether they had NSSI. 30 healthy control group cases(HC). Enzyme linked immunosorbent assay(ELISA) was used to detect the levels of superoxide dismutase(SOD), catalase(CAT), malondialdehyde(MDA), glutathione peroxidase(GPX), and oxidized low-density lipoprotein(OxLDL) in the peripheral blood of the subjects. The Hamilton depression rating scale(HAMD-17) was used to assess the patient′s condition, and the Ottawa self-injury inventory(OSI) was used to quantitatively evaluate the self-injury frequency of NSSI group patients.
Results :The levels of SOD, CAT,MDA,GPX and OxLDL in the patient group were significantly higher than those in the control group(P<0.05). The levels of SOD, CAT, MDA,GPX and OxLDL in the NSSI subgroup were significantly higher than those in the Non-NSSI subgroup and the control group(P<0.05).The duration of the NSSI subgroup was positively correlated with the levels of SOD,CAT,and MDA(r=0.504,P=0.004; r=0.568,P=0.001; r=0.404,P=0.024),and the HAMD-17 score was positively correlated with the levels of SOD,CAT,and MDA(r=0.573,P=0.001; r=0.577,P=0.001; r=0.477,P=0.007). The frequency of self-injury was positively correlated with the levels of SOD and MDA(r=0.558,P=0.001; r=0.494,P=0.005).
Conclusion : The OS level of patients with depression is significantly higher than that of the healthy population,and among them,patients with depression accompanied by NSSI have a more significant increase in oxidative stress level. Elevated levels of OS may affect the severity,duration,and frequency of self-injurious behavior in patients with depression accompanied by NSSI.
- Full text:2026012318455919328伴非自杀性自伤的抑郁障碍患...化应激水平异常及相关性分析_张爱国.pdf
