Expression and clinical prognostic value study of GPR15 and FOXP3 in colorectal carcinoma
10.19405/j.cnki.issn1000-1492.2025.03.013
- Author:
Jinglu Sun
1
;
Li Tong
2
;
Nana Wang
1
;
Yangyang Wu
1
;
Qiong Wu
3
Author Information
1. Clinicopathological Center，Anhui Public Health Clinical Center( North District，The First Affiliated Hospital of Anhui Medical University) ，Hefei 230011
2. Dept of Pathology，Zhenjiang First People’s Hospital， Zhenjiang 212002
3. Dept of Pathology，Bengbu Medical University，Bengbu 233030; Dept of Pathology，The First Affiliated Hospital of Bengbu Medical University，Bengbu 233004
- Publication Type:Journal Article
- Keywords:
colorectal carcinoma;
GPR15;
FOXP3;
immunohistochemistry;
prognosis
- From:
Acta Universitatis Medicinalis Anhui
2025;60(3):480-487
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of GPR15 and FOXP3 in colorectal carcinoma(CRC) tissues and their clinical prognostic values.
Methods :A total of 132 patients with CRC underwent radical surgery were collected. The control group selected the normal mucosal tissues more than 5 cm away from the edge of the cancer focus. Immunohistochemistry(Envision two-step method) was used to detect the expression levels of GPR15 and FOXP3 in CRC and adjacent tissues, and analyze their relationships with clinicopathological factors of colorectal cancer. Kaplan-Meier method was used to draw the survival curve to analyze the correlation between the expressions of GPR15 and FOXP3 and the survival prognosis of patients with CRC. The factors influencing prognosis of patients with colorectal cancer were analyzed by Cox regression.
Results :The immunohistochemistry showed that the expression levels of GPR15 and FOXP3 in CRC were significantly higher than those in normal colorectal mucosal tissues(P<0.05). The expression of GPR15 in CRC tissues was correlated with location, nerve invasion and TNM stage; FOXP3 expression was correlated with sex(P<0.05).Both expressions were not significantly correlated with the clinicopathologic features of age, tumor size, differentiation degree, tissue type, depth of invasion, tumor budding, vascular invasion and lymph node metastasis. Correlation analysis showed that there was no significant correlation between GPR15 and FOXP3 expression(Kappa=-0.019,P>0.05). The survival prognosis of GPR15 positive group was significantly worse than that of negative group(log-rank: χ2=4.3,P=0.039);while the survival prognosis of FOXP3 positive group was significantly better than that of negative group(log-rank: χ2=7.3,P=0.007).Age ≤55 years, positive GPR15 and negative FOXP3 were independent risk factors for poor prognosis in patients with CRC(P<0.05).
Conclusion:The expression levels of GPR15 and FOXP3 in CRC are significantly higher than those in paracancer tissues, GPR15 and FOXP3 are expected to become new tumor markers for early screening, accurate treatment and prognosis assessment of CRC.
- Full text:2026012318101687216GPR15与FOXP3在结...的表达及其临床预后价值研究_孙晶璐.pdf
