Association of GPX4 gene polymorphisms with non-cardia gastric cancer
10.19405/j.cnki.issn1000-1492.2025.03.003
- VernacularTitle:GPX4基因多态性与非贲门胃癌的关系
- Author:
Yaru Chen
1
;
Fang Gao
2
;
Wenjie Dong
1
;
Ning Chu
1
;
Yanbin Jia
1
Author Information
1. School of Basic Medicine and Forensic Medicine，Baotou Medical college，Baotou 014040
2. School of Medical Technology and Anaesthesia，Baotou Medical college，Baotou 014040
- Publication Type:Journal Article
- Keywords:
glutathione peroxidase 4;
single nucleotide polymorphisms;
non-cardia gastric cancer;
haplotype
- From:
Acta Universitatis Medicinalis Anhui
2025;60(3):399-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the role of single nucleotide polymorphisms(SNP) of glutathione peroxidase 4(GPX4) gene in the risk of non-cardia gastric cancer.
Methods:A total of 1 031 samples were selected, including 506 normal examiners and 525 patients with non-cardia gastric cancer.GPX4rs4807542, rs713041, rs2074451 and rs3746162 were genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Unconditional Logistic regression was used to analyze the relationship between each SNP with the risk of non-cardia gastric cancer under the four genetic models.
Results :The CT+TT genotype of rs713041 reduced the risk of non-cardia gastric cancer compared with the CC genotype(OR=0.699, 95%CI: 0.537-0.910). The GT+TT genotype of rs2074451 reduced the risk of non-cardia gastric cancer compared with the GG genotype(OR=0.681,95%CI: 0.520-0.893). The G-C-G-C haplotype, constructed by the four SNPs ofGPX4, was related to an increased risk of non-cardia gastric cancer(OR=1.262, 95%CI: 1.035-1.539), and G-T-T-C haplotype was related to a decreased risk of non-cardia gastric cancer(OR=0.784, 95%CI: 0.656-0.937). The fourth-order interaction ofGPX4rs4807542, rs713041, rs2074451 and rs3746162 played a synergistic effect in the risk of non-cardia gastric cancer(P<0.05).
Conclusion :GPX4rs713041 and rs2074451 are related to non-cardia gastric cancer susceptibility. The G-C-G-C haplotype composed ofGPX4rs4807542, rs713041, rs2074451 and rs3746162 is a risk factor for non-cardia gastric cancer, while the G-T-T-C haplotype is a protective factor. The interaction betweenGPX4rs4807542, rs713041, rs2074451 and rs3746162 is closely connected with the occurrence of non-cardia gastric cancer.
- Full text:2026012217063291230GPX4基因多态性与非贲门胃癌的关系_陈雅茹.pdf
