Recent research progress of prenatal stress-induced disease by disrupting offspring intestinal microbiota

Author: Yingzhi He ; Cizheng Zeng ; Xuemei Chen ; Yuwei Xie ; Dang Ao ; Ling Liu ; Wen Li
Publication Type:Journal Article
Keywords: prenatal stress; parent; microbiota; imbalance; offspring; disease
From: Acta Universitatis Medicinalis Anhui 2025;60(2):372-377
CountryChina
Language:Chinese
Abstract: Abstract :Prenatal stress is a common, systemic, nonspecific stress response that occurs during pregnancy. The gut microbiota, which is known as the “second genome” of the human body, interacts with all major systems of the body. Changes in the gut microbiota can impact the development and health of infants and young children. Advances in research technology have allowed us to uncover the relationship between prenatal stress and imbalances in offspring intestinal microbiota, as well as the development of multiple systemic diseases. However, the exact mechanisms through which prenatal stress disrupts the gut microbiota of offspring remain incompletely understood. This review summarizes the existing research on diseases caused by prenatal stress disrupting the offspring intestinal flora, and seeks future research directions to expand the understanding of the pathogenesis of infant diseases.
Full text:2026012216473503167产前应激通过破坏子代肠道菌群导致疾病的研究进展_何鎣芝.pdf