Biological functions of cyclin 183 and its effects in disease
10.19405/j.cnki.issn1000-1492.2025.02.026
- Author:
Ruirui Yang
1
;
Shiyu Gao
2
;
Jianchu Wang
2
;
Xiaoyun Bin
3
;
Changli Wang
3
Author Information
1. Institute of Life Sciences , Youjiang Medical University for Nationalities , Baise 533000
2. College of Clinical Medicine , Youjiang Medical University for Nationalities , Baise 533000
3. College of Basic Medical Sciences , Youjiang Medical University for Nationalities , Baise 533000
- Publication Type:Journal Article
- Keywords:
ubiquitination;
RNF183;
endoplasmic reticulum stress;
colorectal cancer;
inflammatory bowel dis⁃ ease;
bladder cancer
- From:
Acta Universitatis Medicinalis Anhui
2025;60(2):366-371
- CountryChina
- Language:Chinese
-
Abstract:
Abstract :Ring finger protein 183(RNF183) is an E3 ubiquitin ligase that catalyzes the covalent attachment of ubiquitin molecules to substrate proteins. RNF183 is expressed in tissues such as kidney and testis, and it is mainly localized to the endoplasmic reticulum, Golgi apparatus, and lysosomes in cells. As one of the components of the endoplasmic reticulum membrane, it participates in the endoplasmic reticulum stress-responsive pathway that affects cellular and protein ubiquitination. In recent years, the study of E3 ubiquitin ligase member-RNF183 with various diseases such as colorectal cancer, endometrial cancer and bladder cancer has gradually increased. In this review, the role of RNF183 in colorectal cancer, inflammatory bowel disease and other diseases, as well as biological functions such as endoplasmic reticulum stress are summarized, aiming to provide reference ideas for the study of related diseases.
- Full text:2026012216452227445环指蛋白183的生物学功能及其在疾病中的作用_杨睿睿.pdf
