Effect of combined pulmonary arterial hypertension on the prognosis of hypertrophic cardiomyopathy
10.19405/j.cnki.issn1000-1492.2025.02.024
- Author:
Nuerlan Nazila
1
;
Yongqi Tang
1
;
Aikemu Ainiwaer
2
;
Maimaitiyiming Dilinuer
1
Author Information
1. Dept of General Cardiology, The First Afiliated Hospital of Xinjiang Medical University, Urumqi 830011
2. College of Pharmacy, Xinjiang Hotan University,Hotan 848000
- Publication Type:Journal Article
- Keywords:
hypertrophic cardiomyopathy;
myocardial fibrosis;
pulmonary hypertension;
pulmonary artery systolic pressure;
heart failure;
adverse event
- From:
Acta Universitatis Medicinalis Anhui
2025;60(2):351-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To study the risk factors of poor prognosis in patients with hypertrophic cardiomyopathy(HCM) complicated with pulmonary hypertension(PH).
Methods :Patients(n=154) diagnosed with HCM were selected.According to whether they were complicated with pH,the patients were divided into control group(n=119 cases) and case group(n=35 cases),and the baseline and echocardiographic data were compared and analyzed.Then the patients in the case group were divided into PH 1 group(n=25 cases) and PH 2 group(n=10cases) according to the degree of elevation of pulmonary artery systolic pressure(PASP).The patients were followed up and recorded whether the patients had adverse events within 2 years.Cox regression analysis was used to analyze the risk factors of poor prognosis in patients with HCM with PH.KM survival curves were plotted for the survival risk analysis of patients with HCM complicated with PH.
Results :The prevalence of pH in HCM patients was 22.73%.Compared with the control group,women(48.57%) and patients with arrhythmia(42.86%) accounted for a larger proportion in the case group(P<0.01).Spearman correlation analysis of the patients in the case group showed that female,moderate and severe valve regurgitation were positively correlated with the changes of PASP.Atrial diameter,LACI,left ventricular mass fraction and E/e' value all increased with the increase of PASP level(P<0.05),and LVEF decreased with the increase of PASP level(P<0.001).The incidence of adverse events in HCM patients was 25.97%.Log Rank test showed that there was a statistically significant difference in the cumulative survival rate between PH 1 group and PH 2 group(P<0.001).Cox regression analysis showed that PASP(HR=1.123,95% CI=1.033-1.221) and E/e'(HR=1.131,95% CI=1.054-1.213) were independent risk factors for adverse events in HCM patients with PH within 2 years(P<0.05).
Conclusion :Both PASP levels and E/e' values are independent risk factors for developing poor prognosis in patients of HCM with PH.
- Full text:2026012216380001445合并肺动脉高压的肥厚型心肌...患者发生不良预后的危险因素_娜孜拉·努尔兰.pdf
