Electroencephalographic characteristics of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes
10.19845/j.cnki.zfysjjbzz.2025.0202
- VernacularTitle:线粒体脑肌病伴高乳酸血症和卒中样发作的脑电图特征
- Author:
Wanqing SUN
1
;
Jianmin LIANG
1
Author Information
1. Department of Pediatric Neurology， The First Hospital of Jilin University，Jilin Provincial Key Laboratory of Pediatric Neurology， Changchun 130021， China
- Publication Type:Journal Article
- Keywords:
Mitochondrial encephalopathy;
Electroencephalography;
Epilepsy;
Magnetic resonance imaging;
Child
- MeSH:
Electroencephalography
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(12):1119-1125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the electroencephalographic （EEG） manifestations of children with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes （MELAS）， to explore the EEG characteristics of such patients and their correlation with neuroimaging findings， and to provide a reference for the early clinical diagnosis of MELAS. Methods A retrospective analysis was performed for the EEG and neuroimaging data of 11 children who were admitted to Department of Pediatric Neurology， The First Hospital of Jilin University， from January 2016 to December 2024 and were diagnosed with MELAS by genetic testing. Results There were varying degrees of EEG background abnormalities in the children with MELAS. Interictal epileptiform discharges predominantly involved the posterior head region. Seizures mainly manifested as focal seizures， frequently originating from the posterior head regions. Serial EEG and neuroimaging examinations showed changes in lesion sites over time， with consistent localization of lesions in more than half of the cases based on the two examinations， predominantly involving the posterior head regions. Conclusion In clinical practice， most children with MELAS have the initial manifestation of seizures， and the possibility of MELAS should be considered in case of the characteristic changes in EEG and imaging examinations， so as to provide help for early identification and diagnosis.
