Association between insomnia and anxiety：An analysis based on genetic correlation and bidirectional two-sample Mendelian randomization
10.19845/j.cnki.zfysjjbzz.2025.0200
- VernacularTitle:遗传相关性、双向双样本孟德尔随机化分析失眠与焦虑症的关系
- Author:
Zhifeng LIN
1
,
2
;
Jinxiang CHENG
1
,
2
Author Information
1. 19845/j.cnki.zfysjjbzz.
2. 0200
- Publication Type:Journal Article
- Keywords:
Insomnia;
Anxiety;
Mendelian randomization;
Causal relationship;
Linkage Disequilibrium Score Regression
- MeSH:
Insomnia;
Anxiety
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(12):1100-1110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential genetic mechanisms of insomnia and anxiety and the bidirectional causal relationship between them using Linkage Disequilibrium Score Regression （LDSC） and Mendelian Randomization （MR）. Methods Based on the data from genome-wide association studies， LDSC was used to analyze the genetic correlation of insomnia with anxiety and its subtypes. The inverse variance weighted （IVW） method was used as the main analytical method， supplemented by MR-Egger regression， weighted median， the simple model method， and weighted model. The Cochran’s Q test was used for heterogeneity testing， MR-Egger was used for pleiotropy testing， and the leave-one-out method was used for sensitivity analysis. Results The LDSC analysis revealed the genetic correlation of insomnia with anxiety and its subtypes. The results of IVW analysis showed that insomnia had a causal relationship with the increased risk of anxiety （OR=1.448，95%CI 1.025‒2.045，P=0.036，PFDR=0.178） and generalized anxiety disorder （OR=2.098，95% CI 1.105‒3.986， P=0.024， PFDR=0.314）. Conversely， the reverse MR analysis showed a causal relationship between generalized anxiety disorder and the increased risk of insomnia （OR=1.010， 95% CI 1.003‒1.017， P=0.008， PFDR=0.329）. No significant horizontal pleiotropy was detected for the instrumental variables （P>0.05）， and the sensitivity analysis showed that the results of MR analysis were stable. Conclusion Insomnia may be used as a risk factor for anxiety， and there is a genetic correlation between the two diseases.
