Factor analysis of pulmonary multidrug-resistant Escherichia coli infection in patients with active tuberculosis
10.19405/j.cnki.issn1000-1492.2025.02.022
- Author:
Xiaofei Shen
1
;
Yaxue Liang
2
;
Wenjuan Xia
3
;
Xiaoyun Fan
4
Author Information
1. Dept of Geriatric Respiratory and Critical Care Medicine , The First Afiliated Hospital of Anhui Medical University, Hefei 230022 ; Dept of Respiratory and Critical Care Medicine , Anhui Chest Hospital , Hefei 230022
2. Dept of Tuberculosis , Anhui Chest Hospital , Hefei 230022
3. Dept of Respiratory and Critical Care Medicine , Dept of Tuberculosis , Anhui Chest Hospital , Hefei 230022
4. Dept of Geriatric Respiratory and Critical Care Medicine , The First Afiliated Hospital of Anhui Medical University, Hefei 230022
- Publication Type:Journal Article
- Keywords:
lung infection;
multidrug resistant escherichia coli;
active tuberculosis;
influencing factors;
risk fac⁃ tors;
screening
- From:
Acta Universitatis Medicinalis Anhui
2025;60(2):338-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To analyze the influencing factors associated with the coexistence of multidrug-resistantEscherichia coli(MDR-ECO) infection and active tuberculosis(ATB) in patients with lung infections.
Methods:A total of 204 hospitalized patients with lung infections caused by MDR-ECO were enrolled. Among them, patients with coexisting ATB were identified and assigned to the observation group. Univariate and multivariate Logistic regression analysis were performed to identify the risk factors for the coexistence of MDR-ECO lung infection and ATB.
Results : Factors such as patient age, neutrophil count, hemoglobin level, malignancy, rheumatoid arthritis, history of antibiotic exposure, and history of surgery within the past year were found to be influencing factors for the coexistence of MDR-ECO lung infection and ATB(allP<0.05). Specifically, advanced age(95%CI: 0.949-0.992,P=0.008), decreased neutrophils(95%CI: 0.750-0.922,P<0.001), and a history of antibiotic exposure(95%CI: 1.202-2.596,P=0.004) were identified as risk factors.
Conclusion : Some patients with MDR-ECO lung infections are prone to coexisting with ATB. Therefore, it is recommended to strengthen ATB screening among high-risk patients, including those at peak ages for susceptibility, with low neutrophil counts, and with a history of antibiotic exposure.
- Full text:2026012216081902136肺部多耐药大肠埃希菌感染患...合并活动性结核病的因素分析_申晓菲.pdf
