Hierarchical brain structural alterations in patients with white matter hyperintensity-related cognitive impairment based on morphometric similarity gradient
10.19845/j.cnki.zfysjjbzz.2025.0196
- VernacularTitle:基于形态相似性梯度的脑白质高信号相关认知障碍患者大脑层级结构改变研究
- Author:
Jingxian XU
1
;
Haifeng CHEN
1
;
Yun XU
1
Author Information
1. Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University， Nanjing 210008，China
- Publication Type:Journal Article
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(12):1077-1084
- CountryChina
- Language:Chinese
-
Abstract:
Morphometric similarity gradient;White matter hyperintensity;Connectivity gradient:Objective To investigate the change in morphometric similarity gradient in patients with white matter hyperintensity （WMH）-related cognitive impairment and its influence on cognitive function. Methods Baseline and neuroimaging data were collected from 141 healthy controls （HC group）， 66 patients with WMH and normal cognition （WMH-NC group）， and 134 patients with WMH and cognitive impairment （WMH-CI group）. The difference in gradient was compared between groups based on the morphometric similarity gradient analysis. The mediating effect model was used to investigate the association between WMH volume，plasma biomarkers for nerve injury， gradient， and cognitive function. Results The research findings showed significant aberrant alternations in morphometric similarity gradient， with a significant increase in variability in the second gradient （P=0.036， not surviving FDR correction）. There was a significant negative correlation between the second gradient and geodesic distance （Pspin<0.001）. In addition，visual cortex gradient played a key mediating role in the association between p-tau181/WMH volume and visuospatial function. Conclusion Patients with WMH-related cognitive impairment have aberrant macroscopic connectivity patterns of the cortex. The aberrant pattern of regional cortex mediates the process in which p-tau181 and WMH volume affect cognitive function， which provides a new perspective for understanding the potential structural mechanism of WMH-related cognitive impairment.
- Full text:2026012215480763239基于形态相似性梯度的脑白质高信号相关认知障碍患者大脑层级结构改变研究.pdf
