Role of vascular endothelial growth factor B and fibroblast growth factor in maintenance of skeletal muscle mass
10.19405/j.cnki.issn1000-1492.2025.02.015
- VernacularTitle:血管内皮生长因子B与成纤维生长因子在维持骨骼肌质量中的作用
- Author:
Yanpu Zhao
1
;
Xiaoyu Yang
1
;
Huikang Yu
1
;
Xueling Yang
1
;
Chunhua Yang
1
;
Geng Tian
1
Author Information
1. Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment , College of Pharmacy , Binzhou Medical University , Yantai 264000
- Publication Type:Journal Article
- Keywords:
skeletal muscle;
vascular endothelial growth factor B;
fibroblast growth factor;
gene-knockout mice;
high-fat diet;
FGF6
- From:
Acta Universitatis Medicinalis Anhui
2025;60(2):293-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To verify the role of vascular endothelial growth factor B(VEGFB) in maintenance of skeletal muscle mass under chow-fed and high-fat diet, and to investigate the role of crosstalk between VEGFB and fibroblast growth factor(FGF) signaling pathways in the process.
Methods :Four experimental groups were designed: VEGFB+/+chow-fed diet group, VEGFB-/-chow-fed diet group, VEGFB+/+high-fat diet group, VEGFB-/-high-fat diet group. Skeletal muscles from 24 weeks mice were isolated and weighed. Gene expression association analysis and qPCR experiments were conducted to assess FGFs expression levels.
Results :Under both dietary conditions, VEGFB ablation resulted in reduced muscle mass. Under chow-fed diet condition, 8 FGFs level reduced including 6 paracrine FGFs in the skeletal muscle from VEGFB-/-mice. Under high-fat diet condition, 11 FGFs level decreased including 8 paracrine FGFs in VEGFB-/-mice.
Conclusion :VEGFB may participate in regulating skeletal muscle mass through FGF networks in the skeletal muscles.
- Full text:2026012211085059771血管内皮生长因子B与成纤维...子在维持骨骼肌质量中的作用_赵衍朴.pdf
