Association between PROS1 gene polymorphism and recurrent spontaneous abortion in Baotou Han population
10.19405/j.cnki.issn1000-1492.2025.02.008
- Author:
Pingping Zhao
1
;
Di Wu
2
;
Dechun Li
3
;
Yanguo Wang
4
Author Information
1. Graduate School , Inner Mongolia University of Science and Technology,Baotou 014040; Dept of Laboratory Medicine , The First Afiliated Hospital of Baotou Medical College , Inner Mongolia University of Science and Technology,Baotou 014010
2. School of Basic Medicine and Forensic Medicine , Inner Mongolia University of Science and Technology,Baotou 014040
3. Dept of Laboratory Medicine , The First Afiliated Hospital of Baotou Medical College , Inner Mongolia University of Science and Technology,Baotou 014010
4. Nursing School ,Baotou Medical College , Inner Mongolia University of Science and Technology,Baotou 014040
- Publication Type:Journal Article
- Keywords:
protein S;
PROS1;
single nucleotide polymorphism;
recurrent spontaneous abortion;
PCR-RFLP;
association study
- From:
Acta Universitatis Medicinalis Anhui
2025;60(2):240-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the association between single nucleotide polymorphism(SNP) of PROS1 gene and recurrent spontaneous abortion(RSA) in Baotou Han population.
Methods :158 RSA patients and 158 control subjects were selected as the study subjects, and the activities of protein S, protein C and antithrombin-Ⅲ were measured. The rs13062355, rs6441600 and rs12634349 loci of PROS1 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Non-conditional Logistic regression was used to analyze the correlation between three SNPs of PROS1 gene and the risk of RSA.
Results : The protein S and antithrombin-Ⅲ activities of RSA patients decreased significantly(P<0.05). PROS1 SNP rs13062355 was associated with the risk of RSA under the dominant model: compared with genotype TT, patients with CT+CC genotypes had a reduced risk of RSA(OR=0.398, 95%CI: 0.249-0.638); SNP rs6441600 and rs12634349 were not associated with the risk of RSA(P>0.05). In the haplotypes constructed by PROS1 rs13062355, rs6441600 and rs12634349, Haplotype C-C-C was statistically different between the two groups(P<0.05). The third-order interaction model rs13062355-rs6441600-rs12634349 was associated with the risk of RSA.
Conclusion : PROS1 SNP rs13062355 may be associated with the risk of RSA in Han women in Baotou area. Haplotype C-C-C of PROS1 rs13062355, rs6441600 and rs12634349 reduces the risk of RSA. The third-order model rs13062355-rs6441600-rs12634349 interaction has a synergistic effect on the occurrence of RSA.
- Full text:202601221035166654PROS1基因多态性与包头...汉族人群复发性流产的关联性_赵萍萍.pdf
