Analysis of the association between serum γ-aminobutyric acid levels and the risk of type 2 diabetes mellitus
10.19405/j.cnki.issn1000-1492.2025.01.019
- Author:
Yingtan Nie
1
;
Yanfang Li
1
;
Jinke Han
2
;
Feifei Wu
1
;
Xiaodan Wang
1
;
Li Lin
3
;
Zhen Yan
1
Author Information
1. School of Public Health，Hainan Medical University，Haikou 571199
2. School of Pediatrics，Hainan Medical University，Haikou 571199
3. Dept of Geriatrics，The Second Affiliated Hospital of Hainan Medical University，Haikou 570311
- Publication Type:Journal Article
- Keywords:
γ-aminobutyric acid;
type 2 diabetes;
oxidative stress;
risk of onset;
dose-response relationship;
case-control study
- From:
Acta Universitatis Medicinalis Anhui
2025;60(1):136-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To explore the association between serum γ-aminobutyric acid ( GABA) levels and the risk of developing type 2 diabetes( T2DM) ．
Methods : 187 cases of T2DM patients attending the hospital were selected as the T2DM group，and 187 cases of non-T2DM population attending the same period of time were selected as the control group according to age ( ± 3 years) and gender 1 ∶ 1．On-site questionnaires and physical examination were conducted for the study subjects，and serum levels of GABA，Malondialdehyde ( MDA) and activities of superoxide dismutase ( SOD) and Glutathione peroxidase ( GSH-Px) were detected by using ELISA kits．The differences in the levels of GABA and oxidative stress indicators ( SOD，GSH-Px，MDA) between the two groups were compared， and the correlation between GABA and oxidative stress indicators was analyzed by Spearman's method; GABA and oxidative stress indicators were divided into three groups according to their control quartiles，respectively ［low level group ( Q1: ＜P25) ，medium level group ( Q2: P25 －P75) ，high level group ( Q3: ＞P75) ］，and conditional logistic regression was applied to analyze the relationship between GABA，oxidative stress indicators and the risk of develo- ping T2DM; the dose-response relationship between GABA，oxidative stress indicators and the risk of developing T2DM was analyzed by using restricted cubic spline ( RCS) ．
Results :T2DM group ( P＜0. 05) ．Spearman's correlation analysis showed that GABA level was positively correlated with SOD and GSH-Px activities and negatively correlated with MDA level ( P＜0. 001) ．Conditional logistic regression analysis showed that medium levels of SOD and GSH-Px as well as medium and high levels of GABA were protective factors for T2DM compared with low levels in each group ( P＜0. 05) ．RCS results showed that a negative dose-response relationship between GABA，GSH-Px and the risk of developing T2DM，and SOD showed a trend of decreasing and then increasing the risk of developing T2DM ( P＜0. 05) ．
Conclusion :Serum GABA levels have been associated with the risk of developing T2DM．As serum GABA levels increase，the risk of developing T2DM may decrease．
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