Research progress on the effects of exercise on gut microbiota among children with autism spectrum disorder
10.16835/j.cnki.1000-9817.2025359
- VernacularTitle:运动对孤独症谱系障碍儿童肠道菌群影响的研究进展
- Author:
PAN Xiang, GAO Yibo, JIANG Lupei, CHEN Xiaoxiao, WANG Yibei, ZHAO Deqiang, ZHANG Yanfeng
1
Author Information
1. China Institute of Sport Science, Beijing 100061, China
- Publication Type:Journal Article
- Keywords:
Motor activity;
Autistic disorder;
Gast rointestinal tract;
Bacteria;
Child
- From:
Chinese Journal of School Health
2025;46(12):1815-1819
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:To investigate the effects of exercise on gut microbiota(GM) among children with autism spectrum disorder(ASD)，the review provides an in depth summary of the three core biological pathways through which exercise modulates the GM: repairing the integrity of the intestinal barrier to inhibit lipopolysaccharide mediated neuroinflammation; optimizing key metabolites, such as short chain fatty acids, to reshape gut-brain communication; synergistically regulating the tryptophan-kynurenine metabolic pathway and vagus nerve signaling to balance neurotransmitters. These interconnected pathways not only alleviate gastrointestinal discomfort but also provide a solid biological foundation for improving the core behavioral symptoms of ASD, such as social deficits and repetitive behaviors. Future research should focus on establishing standardized exercise intervention protocols, validating the efficacy of these key biological pathways using multi omics approaches, and exploring combined intervention strategies. The results of corollary studies will provide a more robust scientific basis for precision rehabilitation of children with ASD.
