Research progress on the anti-nasopharyngeal carcinoma effect of traditional Chinese medicine based on MAPK signaling pathway
- VernacularTitle:基于MAPK信号通路探讨中药抗鼻咽癌作用的研究进展
- Author:
Yuanyuan LI
1
;
Yang CAO
1
;
Yuyin JIANG
1
;
Xinyue ZHANG
1
;
Jingbo LI
2
Author Information
1. Dept. of Otorhinolaryngology，Second Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450002，China;Dept. of Otorhinolaryngology，the Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450011，China
2. Dept. of Otorhinolaryngology，Second Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
mitogen-activated protein kinase;
signaling pathway;
nasopharyngeal carcinoma
- From:
China Pharmacy
2026;37(1):117-123
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma （NPC） is a malignant tumor originating from the mucosal epithelium of the nasopharynx. In recent years， its incidence and mortality rates have shown a continuous upward trend， and there is still a lack of therapeutic regimens with both favorable efficacy and safety in clinical practice. Mitogen-activated protein kinase （MAPK） signaling pathway plays a key regulatory role in biological processes such as cell proliferation， differentiation， apoptosis and invasion. It is widely involved in the occurrence and progression of NPC， and serves as an important target in the research field of anti-NPC therapy. This article systematically elaborates on the mechanism of action of the MAPK signaling pathway in NPC， and reviews the research status regarding the anti-NPC effect of active components of traditional Chinese medicine （TCM） and TCM compound prescriptions by regulating this signaling pathway. The results show that TCM active components， including flavonoids （luteolin， maackiain， baicalein， etc.）， alkaloids （picrasidine Ⅰ， tetrandrine， etc.）， terpenoids （bakuchiol， cantharidic acid）， as well as traditional Chinese medicine compound formulas （such as Biyan jiedu capsules and Yiqi jiedu formula） can exert effects including inducing autophagy and apoptosis of NPC cells， promoting pyroptosis， reversing drug resistance， blocking epithelial-mesenchymal transition， weakening cell stemness and arresting cell cycle progression by regulating the MAPK signaling pathway， thereby inhibiting the occurrence and development of NPC through multiple pathways.
