Research progress and clinical application prospects of heparin-binding protein in organ transplantation
10.12464/j.issn.1674-7445.2025238
- VernacularTitle:肝素结合蛋白在器官移植中的作用研究进展与临床应用前景
- Author:
Chengchang ZHANG
1
;
Ruozhu LI
1
;
Yeqiming WANG
1
;
Chen DAI
1
Author Information
1. Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:ExpertForum
- Keywords:
Heparin-binding protein;
Organ transplantation;
Biomarker;
Inflammatory response;
Rejection;
Ischemia-reperfusion injury;
Infection;
Immune regulation
- From:
Organ Transplantation
2026;17(1):51-60
- CountryChina
- Language:Chinese
-
Abstract:
Heparin-binding protein (HBP) is a pro-inflammatory granule protein released by activated neutrophils, known for its role in modulating vascular permeability and its pathological significance in infectious diseases. In recent years, HBP has garnered attention due to its immune-activating effects in contexts such as sepsis, acute lung injury and organ transplantation. It has been proposed as a potential biomarker for early detection of infection and inflammation. While preliminary progress has been made in animal studies, clinical evidence remains limited. Therefore, this article focuses on the mechanism of action of HBP in transplantation-related complications, explores its potential pathways for predicting infection risk, mediating ischemia-reperfusion injury and rejection, and evaluates the feasibility of intervention strategies such as neutralizing antibodies, heparin derivatives and albumin. The pivotal role of HBP in regulating inflammatory responses post-transplant may offer a novel target for postoperative infection monitoring and personalized therapeutic interventions.
