The role and clinical application progress of macrophages in antibody-mediated rejection in kidney transplantation
10.12464/j.issn.1674-7445.2025237
- VernacularTitle:巨噬细胞在肾移植抗体介导的排斥反应中的作用及临床应用进展
- Author:
Huan TANG
1
;
Zeping GUI
1
;
Min GU
1
;
Zijie WANG
1
Author Information
1. Department of Urology, Jiangsu Key Laboratory of Urological Disease Prevention and Treatment, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210003, China.
- Publication Type:ExpertForum
- Keywords:
Macrophage;
Kidney transplantation;
Antibody-mediated rejection;
Donor specific antibody;
Interferon-γ;
Inflammation;
Fibrosis;
Immunotherapy
- From:
Organ Transplantation
2026;17(1):44-50
- CountryChina
- Language:Chinese
-
Abstract:
Kidney transplantation is the most effective treatment for end-stage renal failure, and antibody-mediated rejection remains the leading cause of late allograft loss. Macrophages, as central effectors of innate immunity, play a crucial role in the initiation, progression and tissue damage of antibody-mediated rejection. This article reviews the spatiotemporal dynamic evolution of macrophage polarization status in different stages of antibody-mediated rejection, the fine regulation of key signaling pathways for macrophage polarization, macrophage related molecules and the application prospects of targeted macrophage therapy. In depth analysis of the research progress of macrophages in antibody-mediated rejection, aiming to provide important theoretical basis for the development of precision diagnostic tools based on macrophages and novel immune intervention targets for antibody mediated rejection, ultimately promoting the improvement of long-term prognosis in kidney transplantation.
