Research progress on the role of antigen-presenting cells in xenotransplantation
10.12464/j.issn.1674-7445.2025232
- VernacularTitle:抗原提呈细胞在异种移植中的作用研究进展
- Author:
Kankan SHUI
1
;
Haoran ZHOU
1
;
Ye XU
2
;
Qiulin LUO
2
;
Tengfang LI
1
;
Hedong ZHANG
1
;
Longkai PENG
1
;
Helong DAI
1
Author Information
1. Department of Kidney Transplantation, the Second Xiangya Hospital of Central South University, Hunan Provincial Clinical Research Center for Organ Transplantation, Changsha 410011, China.
2. Department of Kidney Transplantation, the Second Xiangya Hospital of Central South University, Hunan Provincial Clinical Research Center for Organ Transplantation, Changsha 410011, China;.
- Publication Type:Editorial
- Keywords:
Xenotransplantation;
Rejection;
Antigen-presenting cell;
Macrophage;
Dendritic cell;
B cell;
Immune regulation;
Immune tolerance
- From:
Organ Transplantation
2026;17(1):9-15
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is an effective alternative treatment for patients with end-stage organ failure. However, the shortage of donor organs has limited the widespread application of clinical transplantation. In recent years, breakthroughs in CRISPR-Cas9 gene editing technology have overcome the barrier of hyperacute rejection in xenotransplantation, offering a potential solution to the organ shortage crisis. Rejection remains a critical factor affecting graft survival. Antigen-presenting cells play a vital role in the initiation and progression of rejection and immune regulation in xenotransplantation. Therefore, in-depth investigation into the role of antigen-presenting cells in xenotransplantation is of great significance. This article summarizes the roles and therapeutic strategies of professional antigen-presenting cells, including macrophages, dendritic cells and B cells in xenotransplantation, aiming to provide insights for future research on immune regulation mechanisms in this field.
