Evidence-based medicine (EBM) integrates clinical expertise, research evidence, and patient preferences to improve care. Despite its significance, challenges in EBM practice persist, particularly in resource-limited settings. This study was done to assess the knowledge, attitudes, practices, and barriers to EBM among resident physicians at Southern Isabela Medical Center (SIMC).

A descriptive cross-sectional study was conducted among 66 resident physicians at SIMC using the validated Evidence-Based Medicine Questionnaire (EBMQ). By purposive sampling, EBMQ was distributed online. Data on demographics, EBM knowledge, attitudes, practices, and barriers were analyzed using frequency and proportions.

The majority demonstrated fair knowledge (50%) of EBM resources and terms, with EBM (from BMJ) being the most utilized EBM-specific resource, and “randomized controlled trials” being the most understood concept. Attitudes were predominantly positive, with 98.5% acknowledging EBM’s role in improving patient care. However, practical application was inconsistent; while 65.2% regularly searched literature, only 43.9% critically appraised evidence. Barriers included limited EBM training and awareness of resources, inadequate facility resources, and patient preferences.

Resident physicians at SIMC possess positive attitudes and fair knowledge of EBM but face challenges in its practical application. Institutional efforts to enhance training, resource access, and infrastructural support are essential to improve EBM practice.