Depression is a mental health condition that affects more than 3.3 million Filipinos. Screening of adults and elderly patients is recommended with the use of validated tools like the Patient Health Questionnaire (PHQ-2 or PHQ-9) or the Geriatric Depression Scale-15 (GDS-15). The two-step approach can be followed for adults by using the PHQ-2 first, followed by the PHQ-9 if the PHQ-2 tests positive. Geriatric patients may be screened using the GDS-15 tool or PHQ-9. Diagnostic work-up should be done to rule out metabolic or organic conditions that can mimic or cause depression. Diagnosis of depression should be confirmed using the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria. Referral to a specialist should be done in cases of severe depression, psychosis, high suicide risk, severe malnutrition, pregnant adults, or non-response to initial treatment.