Research progress of the multi-target anti-inflammatory drugs based on the arachidonic acid pathway
10.11665/j.issn.1000-5048.2024122703
- VernacularTitle:基于花生四烯酸代谢通路的多靶点抗炎药物研究进展
- Author:
Dan WU
1
;
Longchen CUI
;
Fumei XU
;
Jie WANG
;
Yanli XU
;
Qili ZHANG
;
Jiaojiao LI
;
Lei ZHAO
Author Information
1. 甘肃中医药大学, 兰州 730000;兰州大学第一医院医学检验中心, 兰州 730000;甘肃省高校中藏药化学与质量研究省级重点实验室, 兰州 730000;甘肃省道地药材质量标准化技术研究与推广工程实验室, 兰州 730000;兰州市食品药品检验检测研究院, 兰州 730000
- Publication Type:Journal Article 期刊文章
- Keywords:
inflammation;
arachidonic acid;
anti-inflammatory drugs;
multitarget-drugs
- From:
Journal of China Pharmaceutical University
2025;56(6):782-792
- CountryChina
- Language:Chinese
-
Abstract:
Arachidonic acid can be transformed into a variety of metabolites that trigger an inflammatory response through cyclooxygenase, lipoxygenase, cytochrome P450 enzymes, and other metabolic pathways. Moreover, it plays a key role in the occurrence and development of inflammatory diseases. In recent years, multi-target drugs based on the arachidonic acid metabolic pathway have become an important direction of anti-inflammatory drug research. This article summarizes the opportunities and challenges of arachidonic acid metabolic pathways as well as their interference in the development of anti-inflammatory drugs, reviews the research progress of multi-target drug design, synthesis, and anti-inflammatory activity based on the arachidonic acid metabolic pathway, and discusses the difficulties and prospects of multi-target drugs based on metabolic pathways in anti-inflammatory drug development, aiming to provide some reference and inspiration for the study of multi-target anti-inflammatory drugs based on the arachidonic acid metabolic pathway.
