Research progress of vacuum compression molding technology in pharmaceutical fields
10.11665/j.issn.1000-5048.2024070303
- VernacularTitle:真空压缩成型技术在药剂学中的研究进展
- Author:
Yixuan WANG
1
;
Xin CHEN
;
Lian HE
;
Congcong ZHANG
;
Peiya SHEN
;
Yuan GAO
;
Jianjun ZHANG
Author Information
1. 中国药科大学药学院, 南京 211198;浙江永宁药业股份有限公司, 台州 318020;中国药科大学中药学院, 南京 211198
- Publication Type:Journal Article 期刊文章
- Keywords:
vacuum compression molding;
amorphous solid dispersions;
drug delivery system;
hot melt extrusion;
characterization analysis
- From:
Journal of China Pharmaceutical University
2025;56(5):654-660
- CountryChina
- Language:Chinese
-
Abstract:
Vacuum compression molding (VCM) is a novel technology supporting the research and development of pharmaceutical solid dispersions. It is widely applied due to its precision and convenience in sample preparation. This technology integrates the principles of heating, melting, cooling, and vacuum compression to transform solid powders into shaped solids directly. By selecting different molds, temperatures, and pressures, researchers can prepare samples with diverse characteristics. This paper presents an overview of the equipment composition and working principles of VCM technology, demonstrating its distinct advantages in the formulation screening process of amorphous solid dispersions through comparative analysis with hot melt extrusion using case studies, and introduces its applications in the development of drug delivery systems and rheological characterization analysis, with a perspective on the future development of its functions.
