Relevance of vascular endothelial cell senescence to cardiovascular diseases and pharmacotherapeutic strategy
10.11665/j.issn.1000-5048.2025030701
- VernacularTitle:血管内皮细胞衰老与心血管疾病的相关性及药物治疗策略
- Author:
Jiaxing XU
1
;
Wenting LI
;
Jiayi LAO
;
Kang LIU
Author Information
1. 中国药科大学中药学院中药药理与中医药学系, 南京 211198
- Publication Type:Journal Article 期刊文章
- Keywords:
cardiovascular disease;
endothelial cell;
cellular senescence;
traditional Chinese medicine
- From:
Journal of China Pharmaceutical University
2025;56(5):645-653
- CountryChina
- Language:Chinese
-
Abstract:
Vascular aging plays a key role in the induction of human aging and serves as the pathological basis for the occurrence and development of atherosclerosis (AS), myocardial fibrosis, and hypertension. Research suggests that vascular aging is the initiating link in the aging process of the body, and cellular senescence is a key mechanism of vascular aging. The process of vascular aging mainly involves the senescence of endothelial cells (ECs) and smooth muscle cells. This review, therefore, focuses on the molecular mechanisms related to telomere dysfunction, oxidative stress, and metabolic disorders involved in senescence of ECs, elaborating on the correlation between the senescence of endothelial cells and the development of vascular dysfunction, AS, myocardial fibrosis, hypertension, and other cardiovascular diseases (CVDs), and at the same time, systematically summarizes the relevant treatment strategies with western medicines, traditional Chinese medicine formulas, and monomers, to provide some theoretical reference for subsequent treatment and research.
