Pharmacological mechanism of Tibetan medicine Zuotangkaca pills for the treatment of hypertension based on network pharmacology
10.11665/j.issn.1000-5048.2025040102
- VernacularTitle:基于网络药理学探究藏药佐汤卡擦丸治疗高血压的药理作用机制
- Author:
Sang GENG
1
;
Xinxin ZOU
;
Luobu BAIMA
;
Daozhi ZHAXI
;
Xuejiao JI
;
Renqing DUOJIE
;
Fengjie HUANG
Author Information
1. 西藏藏医药大学附属医院, 拉萨850000;中国药科大学多靶标天然药物全国重点实验室, 南京211198;西藏藏医药大学基础部, 拉萨850000
- Publication Type:Journal Article 期刊文章
- Keywords:
hypertension;
ZTKCW;
network pharmacology;
mechanism
- From:
Journal of China Pharmaceutical University
2025;56(5):624-633
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of Tibetan medicine Zuotangkaca pills (ZTKCW) for the treatment of hypertension was explored by network pharmacology and in vivo experiments. 68 active ingredients of ZTKCW and 518 drug-disease targets were screened by network pharmacology. Eight core components of ZTKCW (vasicolinone, luteolin, (–)-isocorypalmine, esculetin, liquiritigenin, etc.) and eight key targets (AKT1, TNF, IL6, and STAT3, etc.) were screened by network topology analysis. KEGG enrichment analysis showed that the core targets were mainly enriched in lipids and atherosclerosis, JAK/STAT, and inflammation-related pathways. An in vivo experiment was conducted using spontaneously hypertensive rats (SHR), which were gavaged with ZTKCW at doses of 0.41, 0.82, and 1.64 g/kg for 12 weeks, respectively. The results showed that ZTKCW at a dose of 1.64 g/kg significantly reduced both systolic and diastolic pressure in SHR rats and decreased the phosphorylation levels of AKT1, PI3K, STAT3, and JAK2 in the thoracic aorta and heart tissues. This study demonstrates that ZTKCW may exert its antihypertensive effects through PI3K/AKT and JAK2/STAT3 pathways, providing some insights and a theoretical basis for the use of ZTKCW in hypertension.
