Effect of β-adrenergic receptor blockers on the sleep architecture of mice
10.11665/j.issn.1000-5048.2024051402
- VernacularTitle:肾上腺素β受体阻断药对小鼠睡眠结构的影响
- Author:
Jing QU
1
;
Yutao LIANG
;
Lei HAN
;
Ye XING
;
Long WANG
;
Zhuochao LIN
;
Kepeng LIU
;
Guangsen SHI
Author Information
1. 南方医科大学药学院, 广州 510000;中科中山药物创新研究院, 中山 528400;中国科学院上海药物研究所, 上海 200000;中国科学院大学 北京 100010;中山市人民医院麻醉科, 中山 528400
- Publication Type:Journal Article 期刊文章
- Keywords:
β1 -adrenergic receptor blockers;
sleep;
short sleep gene;
Adrb1
- From:
Journal of China Pharmaceutical University
2025;56(4):498-506
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have identified a missense mutation in the β1-receptor (ADRB1-A187V) that exerts a pronounced impact on human sleep, with a noted decrease in protein abundance in vivo. The administration of β-blockers is frequently associated with sleep disturbances in clinical settings. In this study, we assessed the influence of various β-blockers on sleep within mouse models. Our findings indicated that β-blockers could induce varying degrees of arousal, sleep disruption, and a decrease in REMS (rapid eye movement sleep). We examined the dose-dependent effects of metoprolol and nebivolol on both sleep and cardiac functionality in both wild-type and Adrb1-A187V mutant mice. Our data suggested that, in contrast to cardiac effects, higher doses of metoprolol are required to have noted impact on sleep. No genotype effect was observed with metoprolol in terms of sleep or cardiac function. In contrast, the mutant mice demonstrated increased sensitivity to nebivolol, which exacerbated sleep fragmentation and impeded the onset of REMS. This study is expected to provide some reference for minimizing the occurrence of sleep disorders and reducing the adverse reactions of drugs to the greatest extent.
