Cell Autophagy of Digestive System Tumors Induced by Active Ingredients in Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20250528
- VernacularTitle:中药活性成分诱导消化系统肿瘤细胞自噬的研究进展
- Author:
Wenjun LI
1
;
Chengzhi WANG
1
;
Zhenyao YANG
1
;
Mingyang HE
1
;
Gelei ZHAO
2
;
Dongdong LI
2
;
Peimin LIU
2
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450053，China
2. The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
active ingredient in traditional Chinese medicine;
cell autophagy;
digestive system tumor;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):314-320
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most common malignant tumors， digestive system tumors exhibit an increase in the incidence and mortality year by year. Its pathogenesis is complex， making it difficult to carry out early prevention. Autophagy is a process in which cells use lysosomes to degrade their organelles and macromolecules to maintain cellular homeostasis under the regulation of autophagy-related genes. Cellular autophagy has a dual regulatory effect on the tumor microenvironment， which always affects the occurrence and development of digestive system tumors. Therefore， the effect and mechanism of action of cellular autophagy on digestive system tumors have become a hot topic in tumor therapy in recent years. Meanwhile， the remarkable research results of targeted autophagy drugs indicate that cellular autophagy may become an important target for anti-digestive system tumors. Traditional Chinese medicine （TCM） has been widely used in the comprehensive treatment of digestive system tumors with good efficacy. A variety of active ingredients in TCM， such as flavonoids， glycosides， terpenoids， quinones， and alkaloids， can increase the expression of autophagy-associated proteins microtubule-associated protein 1 light chain 3 （LC3）Ⅱ/Ⅰ， autophagy-related gene （ATG）5， ATG7， inhibit the expression of autophagy-related protein p62 ， and induce autophagy in digestive system tumor cells， thereby exerting the anti-digestive system tumor effect. By summarizing the research results in recent years on the modulation of cell autophagy by active ingredients in TCM to fight against digestive system tumors， this paper analyzed the relevant signaling pathways， regulatory factors， and functional characteristics of cell autophagy modulation， so as to elucidate the mechanism by which active ingredients of TCM induce autophagy and to provide ideas and references for clinical application.
