Molecular Mechanism of Programmed Cell Death in Chronic Obstructive Pulmonary Disease and Traditional Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20250542
- VernacularTitle:程序性细胞死亡在慢性阻塞性肺疾病中的分子机制及中医药干预研究进展
- Author:
Xin PENG
1
;
Yunhui LI
2
;
Lei LIANG
1
;
Zheyu LUAN
1
;
Hanxiao WANG
1
;
Haotian XU
1
;
Ziming DANG
1
;
Jihong FENG
2
Author Information
1. Tianjin University of Traditional Chinese Medicine（TCM）， Tianjin 301617，China
2. The Second Affiliated Hospital of Tianjin University of TCM， Tianjin 300250，China
- Publication Type:Journal Article
- Keywords:
programmed cell death;
chronic obstructive pulmonary disease;
molecular mechanism;
traditional Chinese medicine;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):304-313
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease （COPD） is a chronic respiratory disease that poses a significant threat to global health， exhibiting high morbidity， disability and mortality rate， with its prevention and treatment situation becoming increasingly critical. The pathogenesis of COPD is complex， and the underlying cellular and molecular biological mechanisms remain incompletely elucidated. Programmed cell death （PCD） is the process wherein cells actively undergo demise to maintain internal environmental stability in response to certain signals or specific stimuli. Contemporary medical research indicates that the dysregulation of PCD patterns such as apoptosis， necroptosis， pyroptosis， autophagy， and ferroptosis is closely related to the onset and progression of COPD. Clarifying the molecular mechanisms of PCD in COPD may provide novel perspectives for in-depth understanding and prevention of the disease. Traditional Chinese medicine （TCM） is characterized by holistic regulation. In recent years， extensive research has been conducted in the TCM field focusing on modulating apoptosis， necroptosis， pyroptosis， autophagy， and ferroptosis for the treatment of COPD， yielding remarkable achievements. Therefore， this study systematically explored the molecular mechanism of PCD in COPD and reviewed the potential mechanisms and intervention status of TCM targeting PCD in COPD， aiming to provide insights and references for the clinical prevention， treatment and in-depth research of COPD.
