Exploration in Pathological Mechanisms of Myocardial Infarction and Osteoporosis Based on "Heart-bone" Axis Theory
10.13422/j.cnki.syfjx.20251136
- VernacularTitle:基于“心-骨”轴理论探讨心肌梗死和骨质疏松症的病理机制
- Author:
Yuzhuo ZHANG
1
;
Qi SHANG
1
;
Hui REN
1
;
Bin LIU
1
;
Jingzhi ZHANG
1
Author Information
1. The Second Affiliated Hospital of Guangzhou Medical University， Guangzhou 510260，China
- Publication Type:Journal Article
- Keywords:
heart-bone axis;
myocardial infarction;
osteoporosis;
traditional Chinese medicine treatment;
pathological mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):251-257
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction （MI） and osteoporosis （OP）， as two prevalent metabolic diseases with high morbidity and mortality rates， are respectively characterized by cardiovascular system dysfunction and bone homeostasis imbalance， collectively posing significant global public health challenges. While clinically often considered as independent diseases， recent studies have revealed shared pathological mechanisms between the two. This study initiated its exploration from the traditional Chinese medicine concept of the "heart-bone" axis， systematically analyzing the correlation between MI and OP from perspectives including hemodynamics， neuroendocrinology， calcium homeostasis， inflammation and vascular injury， as well as hormone levels. By discussing the pathological mechanisms of "heart disease affecting the bones and bone disease affecting the heart"， the study also elucidated advancements in both Western and traditional Chinese medicine treatments. The goal is to provide novel insights and methodologies for the prevention and treatment of "heart-bone comorbidities"， thereby facilitating comprehensive management of cardiovascular and skeletal diseases.
