Analysis of Animal Models of Retinal Vein Occlusion Based on Clinical Manifestations of Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20250614
- VernacularTitle:基于中西医临床病证特点的视网膜静脉阻塞动物模型分析
- Author:
Xiaoyu LI
1
;
Lina LIANG
1
;
Xiaofeng HAO
1
;
Menglu MIAO
1
;
Mei SUN
1
Author Information
1. National Center for Prevention and Treatment of Senile Eye Diseases with Traditional Chinese Medicine， Eye Hospital of China Academy of Chinese Medical Sciences， Beijing 100040， China
- Publication Type:Journal Article
- Keywords:
retinal vein occlusion;
clinical manifestations in traditional Chinese and Western medicine;
evaluation of animal models;
combination of disease and syndrome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):204-209
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveRetinal vein occlusion （RVO） is the second most common vascular disease leading to vision loss. Since its pathogenesis remains unclear， current Western medical treatments primarily target complications such as macular edema and neovascularization. The main therapeutic approaches include intravitreal injections of anti-vascular endothelial growth factor （VEGF） agents or corticosteroids， laser photocoagulation， and pars plana vitrectomy. However， these treatments cannot fully reverse disease progression or structural damage. Traditional Chinese medicine （TCM） has unique advantages in the clinical diagnosis and treatment of RVO， and integrated Chinese and Western medicine approaches may offer better clinical outcomes. This study， based on the clinical manifestations of RVO， systematically reviews the existing literature and evaluates the alignment of current RVO animal models with clinical manifestations. The aim is to identify the characteristics and limitations of existing models and provide recommendations and prospects for developing RVO animal models featuring the combination of disease and syndrome. MethodsDatabases including CNKI， Wanfang Data， PubMed， and Web of Science were searched with the keywords of "retinal vein occlusion" and "animal model". Model characteristics were assessed based on the diagnostic criteria for diseases and syndromes in both TCM and Western medicine. The alignment of each model with clinical manifestations was analyzed and evaluated. ResultsThe available RVO models were primarily established via methods such as laser photocoagulation， photodynamic therapy， diathermy， intravitreal drug injection， and mechanical modeling. These models demonstrated moderate overall alignment with clinical manifestations， mainly reflecting disease characteristics. However， they generally lack representation of TCM syndrome features. ConclusionExisting RVO models are predominantly based on Western medicine and lack TCM syndrome features. Western medical treatments for RVO have certain limitations， while syndrome differentiation and treatment in TCM offer potential advantages. Future research should focus on developing disease-syndrome integrated animal models that incorporate both pathological features and TCM syndrome characteristics. This approach will enhance the design of RVO models and facilitate both basic and clinical research， which make it a scientifically valuable and necessary endeavor.
