Clinical Efficacy of Qi-regulating and Phlegm-removing Method（Liu Junzitang Combined with Linggang Wuwei Jiangxintang） in Treating AECOPD with Increased EOS
10.13422/j.cnki.syfjx.20260194
- VernacularTitle:理气消痰法（六君子汤合苓甘五味姜辛汤）治疗嗜酸性粒细胞增高型AECOPD的临床疗效
- Author:
Renjie HUANG
1
;
Wangqin YU
1
;
Wuyinuo TANG
2
;
Hong SONG
1
;
Lyuyuan HE
2
;
Wenbo LIN
2
;
Guanyi WU
2
;
Hang HUANG
2
Author Information
1. School of Basic Medical Sciences，Zhejiang Chinese Medical University，Hangzhou 310053，China
2. Jinhua Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University， Jinhua 321017，China
- Publication Type:Journal Article
- Keywords:
Qi-regulating and phlegm-removing method;
acute exacerbations of chronic obstructive pulmonary disease;
eosinophils;
randomized controlled trial;
Liujunzitang;
Linggan Wuwei Jiangxintang
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):149-156
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the efficacy and safety of the Qi-regulating and phlegm-removing method（Liu Junzitang Combined with Linggang Wuwei Jiangxintang） for treating acute exacerbations of chronic obstructive pulmonary disease （AECOPD） with increased eosinophils （EOS）. MethodsSixty-eight AECOPD patients with increased EOS who were hospitalized in the Department of Pulmonary Diseases of Jinhua Traditional Chinese Medicine Hospital from April 2023 to April 2024 were recruited and randomly assigned to an experimental group （EG） or a control group （CG）. Both groups received conventional Western medicine， with the EG additionally receiving Liujunzitang and Linggan Wuwei Jiangxintang. The therapeutic efficacy indicators were measured after the treatment. The main therapeutic efficacy indicators included partial pressure of oxygen （PaO2） and partial pressure of carbon dioxide （PaCO2）. The secondary efficacy indicators included the TCM symptom scores， the COPD Assessment Test （CAT） score， the Modified Medical Research Council （mMRC） Dyspnea Scale score， and the length of hospital stay. The indicators were measured at baseline and on days 3 and 7 of intervention. The safety was evaluated based on the adverse events. ResultsBaseline characteristics were not statistically different between the two groups. Compared with CG， EG showed no significant difference in PaO2 （P=0.773）， PaCO2 （P=0.632） and or CAT score （P=0.336） at on day 3 but better PaO2 （P=0.004）， PaCO2 （P=0.008）， and CAT score （P=0.013） were significantly better at on day 7. Compared with CGAfter treatment， EG had lower TCM syndrome scores of than CG EG on day 3 （P=0.005） and day 7 were significantly decreased （P0.001）. There was no significant difference in mMRC score between the two groups on day 3 （P=0.514） and day 7 （P=0.176） as wasor the length of hospital stay （P=0.915）. The generalized linear mixed model （GLMM） showed that compared with CG， EG had significant improvements over time in PaO2， PaCO2， TCM syndrome symptom scores， CAT score， and mMRC score. ConclusionRegulating qi Qi and removing phlegm combined with conventional Western medicine can significantly alleviateimprove the clinical symptoms and improve the lung function of AECOPD patients with increased EOS increased AECOPDwhich has and demonstrates good safety.
