Research progress of anaphylaxis
10.12025/j.issn.1008-6358.2025.20241143
- VernacularTitle:严重过敏反应的研究进展
- Author:
Hailuan ZENG
1
;
Ling YE
1
;
Meiling JIN
1
Author Information
1. Department of Allergy, Zhongshan Hospital, Fudan University, Shanghai 200032, China;Research Center of Allergy and Diseases, Fudan University, Shanghai 200032, China.
- Publication Type:Review
- Keywords:
anaphylaxis;
epidemiology;
trigger;
treatment
- From:
Chinese Journal of Clinical Medicine
2025;32(5):865-872
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of anaphylaxis has been on the rise in recent years. Drugs and foods are main triggers, and individuals in different regions and age groups have different characteristics. Its pathogenesis includes immune (IgE-mediated and non-IgE-mediated) factors, non-immune factors and idiopathic ones. The clinical manifestations are symptoms and signs of the skin and mucosa, and respiratory, circulatory, digestive, and nervous systems. There is still a lack of laboratory test indices with high sensitivity and specificity to diagnose anaphylaxis. Adrenaline intramuscular injection is the first-line treatment for anaphylaxis, but its usage during emergencies is unsatisfactory. Glucocorticoids are most frequently used in anaphylaxis, but there is controversy over whether they are beneficial. Currently, high-quality clinical cohort studies are needed to provide solid evidence for the epidemiology, diagnosis and treatment of anaphylaxis. This article reviews the research progress on anaphylaxis, aiming to enhance the understanding of anaphylaxis among medical staff.
