Research advances of portal vein thrombosis affecting endoscopic treatment efficacy for esophagogastric varices
10.12025/j.issn.1008-6358.2025.20250332
- VernacularTitle:门静脉血栓对食管胃静脉曲张内镜治疗疗效影响的研究进展
- Author:
Jian WANG
1
;
Yu FU
2
;
Lili MA
3
Author Information
1. Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
2. Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
3. Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China;Endoscopy Center, Zhongshan Hospital (Wusong Branch), Fudan University, Shanghai 200940, China.
- Collective Name:Jiayinaer bolatihan
- Publication Type:Monographicreport:Endoscopicdiagnosisandtreatmentofdigestivesystemdiseases
- Keywords:
liver cirrhosis;
portal vein thrombosis;
esophagogastric varices;
endoscopic treatment;
anticoagulation therapy
- From:
Chinese Journal of Clinical Medicine
2025;32(5):776-784
- CountryChina
- Language:Chinese
-
Abstract:
Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis, impacting the efficacy of endoscopic treatment for esophagogastric varices (EGV) by exacerbating portal hypertension and altering hemodynamics and coagulation function. This paper systematically reviews the pathogenesis of PVT, and its impact on the efficacy of endoscopic therapy for EGV. PVT is closely associated with early hemostatic failure post-endoscopic treatment, elevated rebleeding rate, and elevated long-term mortality. Although anticoagulation therapy facilitates partial thrombus recanalization and reduces portal pressure, its combination with endoscopic treatment requires careful consideration of the bleeding risk. Current clinical practice necessitates optimization of combined therapeutic strategies integrating anticoagulation and endoscopic treatment, complemented by personalized treatment approaches, to improve clinical outcomes.
