The effect of renal denervation on patients with heart failure treated by guideline-directed management and therapy
10.12025/j.issn.1008-6358.2025.20250101
- VernacularTitle:慢性心力衰竭患者规范化药物治疗基础上行去肾神经术的疗效
- Author:
Mingyang XIAO
1
;
Xian YANG
1
;
Xue KUANG
1
;
Wenjiang CHEN
1
;
Jie YANG
1
;
Yuehui YIN
1
Author Information
1. Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
- Publication Type:Monographicreport:Applicationofrenaldenervationinthetreatmentofhypertension
- Keywords:
renal denervation;
heart failure;
dilated cardiomyopathy;
left ventricular ejection fraction
- From:
Chinese Journal of Clinical Medicine
2025;32(6):953-959
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether renal denervation (RDN) could improve the left ventricular ejection fraction (LVEF) of patients with heart failure (HF) on the basis of guideline-directed management and therapy (GDMT). Methods From January 1, 2023 to August 31, 2024, HF patients diagnosed as dilated cardiomyopathy (DCM) who underwent RDN in the Second Affiliated Hospital of Chongqing Medical University were retrospectively enrolled, all patients had received GDMT for at least three months but the LVEF remained below 55%. Parameters of transthoracic echocardiography (TTE) at baseline, during GDMT, and after RDN were compared to analyze whether RDN can further improve the LVEF of patients on the basis of GDMT. Results A total of 7 HF patients diagnosed with DCM were enrolled, the mean age was (52.86±9.86) years old, and 5(71.4%) were male. After an average of (9.29±8.06) months of GDMT, LVEF significantly increased from baseline (34.86%±10.22%) to (44.57%±5.59%, P=0.024).Three months after RDN, LVEF was further significantly improved (54.43%±9.05%, P=0.026). The average follow-up after RDN was (11.00±4.12) months. The LVEF remained stable (54.86%±7.10%, P=0.805), and no adverse events occurred in the patients. Conclusions RDN can further enhance the LVEF of HF patients on the basis of GDMT.
