Clinical profiles and reproductive outcomes of Filipino women of advanced age who underwent autologous in vitro fertilization: A single center study.

Marella A BUGARIN; Virgilio M NOVERO JR

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Clinical profiles and reproductive outcomes of Filipino women of advanced age who underwent autologous in vitro fertilization: A single center study.

Author: Marella A. BUGARIN ¹ ; Virgilio M. NOVERO JR. ²
Author Information

1. Department of Obstetrics and Gynecology, St. Luke’s Medical Center, Quezon City, Metro Manila, NCR, Philippines
2. Section of Reproductive Endocrinology and Infertility, College of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Metro Manila, NCR, Philippines;Center for Advanced Reproductive Medicine and Infertility, St. Luke’s Medical Center-Global City, Taguig, Metro Manila, NCR, Philippines
Publication Type:Journal Article, Original
MeSH: Human; Fertilization In Vitro; Advanced Maternal Age; Embryo Transfer
From: Philippine Journal of Reproductive Endocrinology and Infertility 2025;22(2):35-46
CountryPhilippines
Abstract: BACKGROUND
Advanced maternal age is associated with diminished IVF outcomes, including reduced live birthrates and increased miscarriage risk.
OBJECTIVE
To determine clinical profiles and reproductive outcomes of Filipino women of advanced age who underwent autologous IVF at the Center for Advanced Reproductive Medicine and Infertility at St. Luke’s Medical Center Global City from January 1 , 2018 to December 31, 2024.
METHODS
This retrospective cohort study analyzed 667 Filipino women aged 38 years and above who underwent autologous IVF/ICSI-ET from 2018 to 2024. Clinical profiles and reproductive outcomes were compared across age groups and embryo transfer types.
RESULTS
Results showed significant age-related decline identified in reproductive outcomes such as clinical pregnancy and live birth rates, coupled with elevated miscarriage rates in older women. Frozen embryo transfers demonstrated superior outcomes versus fresh transfers. While PGT-A improved embryo selection, it did not fully mitigate age-related declines.
CONCLUSION
These findings underscore the persistent negative impact of advanced maternal age on IVF success, highlighting the importance of early fertility intervention, individualized treatment strategies, and context-specific research in resource-constrained settings.