Mycetoma is a chronic, progressively destructive granulomatous infection caused by fungi (eumycetoma) or bacteria (actinomycetoma). It is recognized by the WHO as a neglected tropical disease. Despite its presence globally, the incidence and burden in the Philippines remain poorly documented.

To determine the prevalence, clinicodemographic profile, and outcomes of mycetoma diagnosed at the Jose R. Reyes Memorial Medical Center - Department of Dermatology from January 2014 to December 2024.

A retrospective chart review was conducted among patients diagnosed clinically and confirmed either microbiologically and/or histopathologically with mycetoma. Data collected included age, sex, occupation, risk factors, lesion characteristics, causative agent, diagnostic method, treatment, and outcomes.

Four cases of actinomycetoma were identified, all with pedal involvement. The majority were male (75%) and over 40 years old. One patient had an agricultural occupation. Most were from outside Metro Manila. Histopathologic confirmation was present in all cases. Three patients were lost to follow-up. Only the patient treated for over 12 months achieved clinical improvement.

Mycetoma remains a rare but significant disease in the Philippines. Findings support existing literature on male predominance, pedal localization, and the importance of prolonged antimicrobial treatment. Greater surveillance, early diagnosis, and follow-up strategies are essential.