Xuefu Zhuyutang in Malignant Tumor Disease： A Review
10.13422/j.cnki.syfjx.20250623
- VernacularTitle:血府逐瘀汤在恶性肿瘤疾病中的研究进展
- Author:
Jiaqi JI
1
;
Xiaoqing HU
2
;
Yihan ZHAO
1
;
Xuhang SUN
1
;
Dandan WEI
2
;
Junwen PEI
3
;
Shiqing JIANG
1
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2. The First Clinical Medical School， Henan University of Chinese Medicine，Zhengzhou 450000，China
3. Affiliated Cancer Hospital of Zhengzhou University，Zhengzhou 450008，China
- Publication Type:Journal Article
- Keywords:
Xuefu Zhuyutang;
malignant tumor disease;
clinical application;
pharmacological mechanism;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):321-330
- CountryChina
- Language:Chinese
-
Abstract:
Cancer has become a significant global public health issue， severely impacting public health and societal development. Despite advances in tumor treatment methods in recent years and a gradual decline in cancer mortality rates， drug-related adverse reactions and drug resistance remain substantial challenges. Traditional Chinese medicine （TCM） has demonstrated significant clinical efficacy in cancer treatment and small side effects， making it widely applied in the field of oncology. Xuefu Zhuyutang， derived from Yilin Gaicuo， is known for its abilities to invigorate blood circulation， dispel blood stasis， promote Qi flow， and alleviate pain. It was specifically formulated by the esteemed WANG Qingren of the Qing dynasty for the "blood stasis syndrome in the blood mansion" and is commonly used to treat Qi stagnation and blood stasis syndrome. Clinical studies have shown that Xuefu Zhuyutang， when combined with conventional Western medications， produces significant effects in the treatment of malignant tumors such as liver cancer， lung cancer， and cervical cancer. It substantially reduces the incidence of adverse reactions following Western treatments， including radiation esophagitis， radiation encephalopathy， radiation-induced oral mucositis， and edema. Additionally， it alleviates cancer-related pain and fever， blood hypercoagulability， and associated complications such as depression and anxiety， and also mitigates chemotherapy-induced side effects like hand-foot syndrome. Basic research has demonstrated its potential anti-tumor mechanisms， including the inhibition of Wnt/β-catenin signaling pathway activation， suppression of mitogen-activated protein kinase （MAPK） pathway activation， and anti-tumor angiogenesis. Pharmacological studies have revealed that its active components inhibit tumor cell proliferation and migration， induce tumor cell apoptosis， suppress tumor angiogenesis， enhance the cytotoxicity of natural killer cells against tumors， improve the tumor microenvironment， and regulate immune function. This paper reviewed the latest research progress on Xuefu Zhuyutang in the treatment of malignant tumors from four aspects： theoretical exploration， clinical studies， mechanisms of action， and pharmacological basis， aiming to provide insights and methods for the clinical diagnosis and treatment of malignant tumors.
