Animal Model of Chronic Obstructive Pulmonary Disease and Intervention Effect of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20250926
- VernacularTitle:慢性阻塞性肺疾病动物模型及中药干预作用研究进展
- Author:
Jiyu ZOU
1
;
Lijian PANG
2
;
Tianjiao WANG
2
;
Ningzi ZANG
2
;
Zhongxue ZHAO
2
;
Yongming LIU
2
;
Qi SI
1
;
Tianya CAO
1
;
Xuenan MA
1
;
Ying WANG
1
;
Jiaran WANG
1
;
Xiaodong LYU
1
Author Information
1. Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China
2. The Affiliated Hospital of Liaoning University of TCM， Shenyang 110000，China
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease （COPD）;
animal model;
traditional Chinese medicine;
disease-syndrome combination;
model evaluation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):294-303
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease （COPD）， as one of the three major causes of death， is a complex systemic disease with high prevalence， high mortality， high disability， frequent acute exacerbations， and a variety of pulmonary complications. The pathogenesis is complex. Western medicine has no effective specificity scheme for a complete cure. However， multiple-component and multiple-target characteristics of traditional Chinese medicine （TCM） demonstrate significant advantages in COPD treatment through multi-link， multi-pathway， and multi-mechanism intervention. Therefore， exploring the essence of COPD pathogenesis and discovering effective TCM treatment drugs through the application of TCM principles and prescriptions is a key focus of modern research. Animal models are of paramount importance in medical research. It is the first consideration to select appropriate animals， adopt reasonable modeling methods to replicate stable animal models that closely resemble the clinical manifestations and pathophysiological characteristics of COPD， and use appropriate evaluation methods to determine the success of COPD animal models in experimental research. The core of experimental research lies in observing the intervention effect of TCM on COPD animal models， exploring the specific pathways and regulatory mechanisms of TCM on COPD disease， and finding TCM monomers， single herbs， and TCM formulas with definite curative effects. At present， animal model research on COPD mainly involves model establishment， model evaluation， efficacy observation， mechanism exploration， and other aspects. In recent years， there has been no systematic organization， update， and reflection on the relevant research on TCM intervention in COPD animal models. This study reviewed the selection of animals for the COPD model， methods for establishing COPD animal models， model evaluation methods， and the intervention effects of TCM on COPD animal models. It aims to grasp the current research status and identify existing problems for further improvement， in order to provide evidence and support for scientific research and clinical treatment of COPD.
