Traditional Chinese Medicine Against Insomnia by Regulating PI3K/Akt Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20251767
- VernacularTitle:中医药调控PI3K/Akt信号通路治疗失眠的研究进展
- Author:
Suyu HOU
1
;
Dandan LUO
1
;
Xiangye GAO
1
;
Yan ZHANG
1
;
Xijian LIU
1
Author Information
1. School of Traditional Chinese Medicine（TCM），Shandong University of TCM，Jinan 250355，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt） signaling pathway;
insomnia;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):284-293
- CountryChina
- Language:Chinese
-
Abstract:
Insomnia is a sleep disorder characterized by difficulty in falling asleep， sleep maintenance disorder and impaired daytime function. Its pathological mechanism involves multiple factors such as nerve excitability， circadian rhythm， cell apoptosis， oxidative stress injury. As a classical tyrosine kinase signaling pathway， phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt） triggers Akt phosphorylation cascade， inducing inflammatory response， apoptosis， autophagy， oxidative damage， nerve excitability， and circadian rhythm imbalance. Traditional Chinese medicine（TCM） can improve sleep by targeting the PI3K/Akt pathway. Based on this， this paper systematically reviews the research progress on the regulation of PI3K/Akt pathway by traditional Chinese medicine（TCM） for insomnia at home and abroad. These drugs can regulate neuronal excitability by regulating the PI3K/Akt pathway， affect the circadian rhythm， alleviate inflammation， apoptosis， autophagy and oxidative stress， and thus regulate sleep-wake. Furthermore， literature review indicates that the PI3K/Akt signaling pathway may represent a specific pathway underlying phlegm-turbidity disturbing the upper Jiao-type insomnia.
