Analysis of Animal Models of Retinitis Pigmentosa Based on Diagnostic Features of Chinese and Western Medicine
10.13422/j.cnki.syfjx.20241614
- VernacularTitle:基于中西医临床病证特点的视网膜色素变性动物模型分析
- Author:
Xiaoyu LI
1
;
Lina LIANG
1
;
Jiefeng CHEN
1
;
Xiaoxiao ZHU
1
;
Yina QI
1
Author Information
1. ENational Center for Prevention and Treatment of Senile Eye Diseases with Traditional Chinese Medicine，Eye Hospital of China Academy of Chinese Medical Sciences， Beijing 100040， China
- Publication Type:Journal Article
- Keywords:
retinitis pigmentosa;
diagnostic features of both traditional Chinese and Western medicine;
animal model;
alignment with clinical manifestations
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):198-203
- CountryChina
- Language:Chinese
-
Abstract:
Retinitis pigmentosa （RP） is the most common hereditary blinding eye disease in clinical practice， with the pathogenesis remaining unclear. Patients experience progressive apoptosis of retinal photoreceptor cells， accompanied by degeneration of retinal pigment epithelium （RPE） cells. Current Western medical treatments mainly focus on gene therapy and stem cell transplantation， showing limited efficacy. In contrast， clinical observations have confirmed the therapeutic effects of traditional Chinese medicine （TCM） treatments. Establishing an RP animal model that aligns with the diagnostic features of both TCM and Western medicine could help combine the strengths of both approaches， thereby broadening the treatment options for RP. This study categorizes and summarizes the existing RP animal models in terms of classification， types， inheritance patterns， and alignment with clinical manifestations. It is found that current RP models are primarily derived from natural animal models such as RD mice and RCS rats， transgenic animal models like RPE-65 knockout mice and rhodopsin gene knockout mice， and chemically induced models such as those created by monochromatic light exposure or N-ethyl-N-nitrosourea （ENU） administration. These three categories of models focus more on detecting RP-related histopathological， molecular biological， and cellular immunological indicators， but offer limited observation of the overall characteristics of the disease and lack insight into syndrome differentiation. Although RP is a congenital genetic disease， its progression is influenced by acquired factors such as environment， constitution， emotions， and care. Current models do not fully capture the characteristics of this disease. Therefore， establishing an RP animal model based on the diagnostic features of both TCM and Western medicine will have significant implications for future experimental and clinical research.
