Analysis of Animal Models of Dry Age-related Macular Degeneration Based on Clinical Disease-syndrome Characteristics of Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20241418
- VernacularTitle:基于中西医临床病证特点的干性年龄相关性黄斑变性动物模型分析
- Author:
Xiaoyu LI
1
;
Lina LIANG
1
;
Yun GAO
1
;
Jiahao LI
1
;
Jianying YANG
1
;
Xiaoshan ZHANG
1
;
Honghao BI
1
;
Menglu MIAO
1
;
Huiyi GUO
1
Author Information
1. National Center for Prevention and Treatment of Senile Eye Diseases with Traditional Chinese Medicine，Eye Hospital of China Academy of Chinese Medical Sciences， Beijing 100040， China
- Publication Type:Journal Article
- Keywords:
dry age-related macular degeneration;
animal model;
traditional Chinese and Western medicine;
characteristics of disease and syndrome;
fitting degree with clinical characteristics
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):191-197
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveAge-related macular degeneration （AMD） is one of the leading causes of low vision and blindness in people over 50 years old， and dry AMD （dAMD） is one type for which there is currently no clear treatment. On the basis of the diagnosis and clinical characteristics of dAMD in traditional Chinese and Western medicine， this paper evaluated the fitting degrees of existing animal models of dAMD with clinical characteristics according to the evaluation methods of animal models， and put forward suggestions and prospects. MethodsLiterature on animal models of dAMD was searched against database， and the characteristics of the models were assigned according to the diagnosis criteria of diseases and syndromes of traditional Chinese and Western medicine， and the fitting degrees of the models with clinical characteristics were analyzed and evaluated. ResultsAt present， the animal models of dAMD are mainly established targeting complement factors， chemokines， oxidative damage， lipid/glucose metabolism， and natural strains. Most of the models can simulate the major pathological changes of dAMD， showing the fitting degree of 25%-50% with clinical characteristics in Western medicine. However， the evaluation of traditional Chinese medicine （TCM） syndromes， especially the evaluation of secondary syndromes， is missing， and the models present low fitting degrees with the clinical characteristics in TCM. ConclusionExisting animal models of dAMD are mostly established under the guidance of Western diagnostic standards， which reproduce the main disease characteristics of Western medicine and lack observation of TCM syndromes. Future studies can pay attention to the intervention factors and evaluation systems of spleen deficiency Qi deficiency and liver-kidney Yin deficiency syndrome and build the animal model of dAMD with integration of disease and syndrome based on clinical characteristics of traditional Chinese and Western medicine.
