Analysis of Animal Models of Wet Age-related Macular Degeneration Based on Clinical Disease-syndrome Characteristics of Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20251619
- VernacularTitle:基于中西医临床病证特点的湿性年龄相关性黄斑变性动物模型分析
- Author:
Xiaoyu LI
1
;
Lina LIANG
1
Author Information
1. Hospital of Ophthalmology， China Academy of Chinese Medical Sciences， National Center for Prevention and Treatment of Geriatric Eye Diseases of Traditional Chinese Medicine， Beijing 100040， China
- Publication Type:Journal Article
- Keywords:
wet age-related macular degeneration;
combination of disease and syndrome;
animal model;
clinical concordance
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(3):183-190
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveIn recent years， with the deepening trend of population aging in China， the incidence of age-related macular degeneration （AMD） has been rising. Wet age-related macular degeneration （wAMD） is a type of advanced AMD that can cause severe vision loss. Based on the clinical disease-syndrome characteristics of wAMD， this study reviewed and analyzed existing wAMD animal models， including the animals used， modeling methods， and the advantages and disadvantages of each model， aiming to provide references for the establishment and study of wAMD models integrating disease and syndrome. MethodsLiterature on wAMD-related animal models was retrieved from China National Knowledge Infrastructure （CNKI）， Wanfang Data， VIP， and PubMed. Relevant indicators were collected and analyzed， and model characteristics were quantified and evaluated according to the diagnostic criteria of diseases and syndromes in both traditional Chinese medicine （TCM） and Western medicine. ResultsCurrently， the alignment of wAMD models with Western medicine clinical syndromes mainly reflects the characteristics of macular neovascularization （MNV） and fundus changes， with limited observation of visual function. For TCM， scoring mainly focuses on ocular syndromes， while systemic syndromes are insufficiently observed， which is inadequate to fully reflect the complexity of wAMD pathogenesis and manifestations. Among the main models， alignment with Western medicine clinical syndromes is relatively high. Laser photocoagulation-induced models are the most commonly used and show the highest alignment， and their correspondence with the TCM syndrome of “spleen deficiency and dampness retention” is relatively high. ConclusionCurrent models generally show moderate alignment with clinical disease-syndrome characteristics in both TCM and Western medicine， especially with TCM syndromes， where alignment is low. This limits the development and study of models integrating disease and syndrome. Future research should further explore other TCM syndrome types and compound syndromes to establish wAMD animal models with higher alignment with TCM.
