Research progress on the association between biliary microbiota and the presence of biliary tract diseases as well as the postoperative infections
10.19428/j.cnki.sjpm.2025.250212
- VernacularTitle:胆道微生物群与胆道疾病发生及其术后感染关联的研究进展
- Author:
Xinran YANG
1
;
Yuyang ZHOU
2
;
Zhe YAN
3
Author Information
1. School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Tropical Disease Research Center, Fudan University, Shanghai 200032, China
2. First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
3. Department of Hepatobiliary and Pancreatic Surgery, Xuhui Central Hospital ,Fudan University, Shanghai 200031, China
- Publication Type:Review
- Keywords:
microbiota;
biliary tract disease;
infection;
surgery
- From:
Shanghai Journal of Preventive Medicine
2025;37(10):884-888
- CountryChina
- Language:Chinese
-
Abstract:
The biliary microbiota is an important component of the biliary system, the structure changes and dysbiosis of the biliary microbiota are closely related to the occurrence and development of biliary diseases. Recent studies have found that the dysbiosis of the biliary microbiota can lead to the occurrence of various biliary diseases such as cholelithiasis, cholangitis, and biliary tract cancer. However, the specific mechanisms of some of these diseases remain unclear. In addition, the alternation of biliary microbiota may also lead to the occurrence of postoperative complications of biliary diseases, such as the risk of infection increased after laparoscopic cholecystectomy (LC) and endoscopic retrograde cholangiopancreatography (ERCP). Although some studies have begun to explore the connection between biliary microbiota and biliary diseases, most research have mainly focused on a single disease type or specific microorganisms. There has been no comprehensive and systematic review of the overall changes in biliary microbiota across different diseases and their association with post biliary surgery infection.Therefore, this article presents a systematic review of current advances linking the alternations of biliary microbiota to the development of biliary diseases and their postoperative infections, as well as the changes in the biliary microbiota before and after various biliary diseases and their surgeries, aiming to provide insightful methods for the early diagnosis, prevention and treatment of biliary diseases and management of postoperative infections.
