Epidemiological characteristics and influencing factors of SARS-CoV-2 reinfection in community populations in Xuhui District， Shanghai
10.19428/j.cnki.sjpm.2025.250215
- VernacularTitle:上海市徐汇区社区人群新型冠状病毒重复感染的流行特征及影响因素
- Author:
Huiting WANG
1
;
Yanfei GUO
2
;
Chen CHEN
1
;
Junhong YUE
1
;
Qingqing JIA
1
;
Fei WU
3
;
Yanlu YIN
1
;
Jiajie ZANG
4
;
Fan WU
1
Author Information
1. Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China
2. Institute for Chronic Non-Communicable Diseases and Injury Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China
3. School of Public Health, Fudan University, Shanghai 200032, China
4. Institute for Health Hazard Factors Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China
- Publication Type:Journal Article
- Keywords:
SARS-CoV-2;
reinfection;
influencing factor;
Omicron variant;
cohort study
- From:
Shanghai Journal of Preventive Medicine
2025;37(10):803-812
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the epidemiological characteristics and influencing factors of SARS-CoV-2 reinfection by conducting follow-up investigations among community residents who experienced their first SARS-CoV-2 infection between March and June 2022, so as to provide a scientific basis for predicting future epidemic trends and adjusting prevention and control strategies. MethodsA cohort study was conducted in Xuhui District, Shanghai. A total of 1 208 individuals with a documented primary SARS-CoV-2 infection between March and June 2022 were enrolled and followed-up longitudinally. Data were collected using structured questionnaire surveys to assess the reinfection rate, incidence density, and clinical manifestations of SARS-CoV-2 reinfection. A logistic regression model was used to analyze the influencing factors of SARS-CoV-2 reinfection. ResultsA total of 497 SARS-CoV-2 reinfection cases were observed among the 1 208 research subjects, with a reinfection rate of 41.14% and an incidence density of 0.63 cases per 1 000 person-days. The cumulative reinfection rates at 6, 9, 12, 15, and 18 months following the initial infection were 0.08%, 15.31%, 19.04%, 33.53%, and 38.25%, respectively. Compared with the primary infection, reinfection was more likely to be symptomatic, with a greater severity of fever, dry cough, sore throat, and runny nose. Being female, younger age, and symptom duration ≥7 days during the primary infection were identified as influencing factors for SARS-CoV-2 reinfection, while a higher socioeconomic status can reduce the risk of SARS-CoV-2 reinfection. ConclusionSARS-CoV-2 reinfection is relatively common and often symptomatic. Age, gender, income level, and the duration of symptoms during the primary infection are identified as infuencing factors for SARS-CoV-2 reinfection. Continuous monitoring of reinfection in the population is recommended, along with the development of effective strategies to mitigate the impact of reinfection.
