Effect of sex hormones on male osteoporosis: a review

Author: GAO Zengjie ; ZHANG Wangming ; FAN Zhiliang ; LI Lailai ; CHAI Yihui
Publication Type:Journal Article
Keywords: male osteoporosis; bone metabolism; androgen; estrogen
From: Journal of Preventive Medicine 2025;37(12):1239-1241
CountryChina
Language:Chinese
Abstract: Abstract:The incidence of fragility fractures and related mortality caused by male osteoporosis (OP) are both higher than in females. Male bone health was regulated by a sophisticated network involving both androgens and estrogens. Androgens can directly promote bone formation and inhibit bone resorption through androgen receptors on osteoblasts and osteocytes. They can also be converted into estrogens via the action of aromatase and subsequently regulate bone metabolism through estrogen receptors. Declining sex hormone levels, an imbalance in the estrogen-to-androgen ratio, and the resulting disruption in bone metabolic pathways collectively contribute to the development and progression of male OP. Moreover, androgens cannot fully compensate for the bone metabolic imbalance induced by estrogen deficiency. This article reviewed research on the role and mechanism of sex hormones in male OP, as well as studies related to the risks of sex hormone therapy for OP, so as to provide the references for improving control and treatment strategies of male OP.
Full text:2026010414083212968性激素对男性骨质疏松症的影响研究进展.pdf